100例不同年龄组的儿童继发性高血压患者血浆肾素活性、血管紧张素Ⅱ、醛固酮水平分析

The Analysis of Levels of Plasma Renin Activity,AⅡ and ALD Horizontal in 100 Cases of Children of Secondary Hypertension in Different Age Groups

目的儿童继发性高血压不同年龄组血浆肾素活性(plasma renin activity,PRA)、血管紧张素Ⅱ(angiotensinⅡ,AⅡ)、醛固酮(aldosterone,ALD)水平对比及卧位与立位差异。方法收集2016年4月至2017年4月北京中同蓝博临床检验所检测的100例儿童继发性高血压患者按照年龄分为学龄前组(1～7岁)和学龄组(8～14岁),两组均采取卧位和立位的方式进行抽取血样,并通过RIA的方法对两种体位进行检测肾素活性(PRA)、血管紧张素Ⅱ、醛固酮水平统计分析。结果学龄前组患者PRA、AⅡ、ALD水平均高于学龄组患者(P<0.05),卧位儿童继发性高血压患者PRA、AⅡ、ALD水平均低于立位儿童继发性高血压患者(P<0.05)。结论儿童继发性高血压可导致卧立位的PRA、AⅡ、ALD水平差异具有统计学意义,指导临床上对儿童继发性高血压治疗,更好的控制心血管疾病的发生发展。

Objective Children in different age groups of secondary hypertension were analyzed for plasma renin activity （ plasma renin activity, PRA）, angiotensinⅡ （ A Ⅱ）, aldosterone （ALD） and the compared for level difference of supine and upright aldosterone. Methods We collected laboratory test of 100 cases of children with secondary hypertension according to different age from April 2016 to April 2017 in Beijing CIC Clinical,then divided them into preschool group （1-7 year old） and school age group （8-14 years old）. For both groups, we took blood samples in a supine position and a standing position, and measured the two types of position by means of RIA for statistical analysis of PRA, angiotensin Ⅱ, and aldosterone levels. Results For preschool group （1-7 years old） patients, the PRA, A Ⅱ, ALD were higher than those of school-age （8-14 years old） patients （ P 〈 0.05 ）. For children supine patients with secondary hypertension the PRA, A Ⅱ, ALD were lower than patients with secondary hypertension standing child （P 〈 0.05 ）. Conclusion Children with secondary hypertension with lying upright positions can have PRA, A Ⅱ, ALD differently, which can guide secondary hypertension clinical treatment, lead to the better control of cardiovascular disease.