沙丁胺醇联合异丙托溴铵雾化吸入致心律失常监测的前瞻性研究

Prospective study of arrhythmia induced by aerosol inhalation of ventolin combined with ipratropium bromide

目的:监测沙丁胺醇联合异丙托溴铵雾化吸入致心律失常发生的规律和特点,促进临床合理用药。方法:采用前瞻性研究方法观察某三甲医院呼吸科56例患者应用沙丁胺醇联合异丙托溴铵雾化吸入前后心率的变化,对结果进行综合分析。结果:本研究共发生心律失常7例(12.50%),心律失常的发生与年龄及性别均无相关性,大多发生在雾化开始8 min后,发生心律失常的患者中有71.43%存在基础心电图异常。结论:为加强临床用药的安全性,医护人员应警惕沙丁胺醇联合异丙托溴铵雾化后心律失常这一不良反应的发生,根据患者病情合理用药,加强联合雾化后的观察及心率的监测,尽量减少和避免心律失常的发生。

Objective：To monitor the rules and characteristics of arrhythmia induced by aerosol inhalation of ventolin combined with ipratropium bromide,and to promote clinical rational drug use. Methods：A prospective study was conducted to observe the changes of heart rate before and after inhalation of ventolin combined with ipratropium bromide in 56 patients in Department of Respiratory Medicine of a three grade hospital. Results ： Arrhythmia occurred in 7 cases （12.50%）. The occurrence of arrhythmia was not correlated with age and sex. Most arrhythmia occurs in 8 min after the start of atomization and 71.43% of the pa- tients with arrhythmia had abnormal ECG. Conclusion ： In order to strengthen the safety of clinical medication, physicians and nurses should be aware of the adverse effects of inhalation of ventolin combined with ipratropium bromide on cardiac arrhythmias. And health care workers should be aware of rational use of drugs according to the patients＇ condition. Observation of combined atomization should be strengthened to reduce and avoid the occurrence of arrhythmia.