黄芪消渴方联合二甲双胍缓释片对2型糖尿病患者HOMA-IR HOMA-β及肝脏脂肪含量的影响

目的探讨黄芪消渴方联合二甲双胍缓释片治疗2型糖尿病（T2DM）的效果及对患者胰岛β细胞指数（HOMA-β）、胰岛素抵抗（HOMA-IR）、肝脏脂肪含量的影响。方法选择2015年11月至2017年6月T2DM患者90例，随机分为2组，各45例。对照组采用二甲双胍片、格列美脲降血糖治疗，观察组在时照组基础上联合黄芪消渴方治疗，12周为1个疗程。比较两组临床疗效。结果治疗后，观察组空腹血糖、餐后2h血糖水平低于对照组，差异有统计学意义（P〈0．05）；观察组HOMA-B高于对照组，HOMA-IR、肝脏脂肪含量均低于对照组（P〈0.05）；观察组总有效率91．11％，高于对照组73．33％，差异有统计学意义（P〈0.05）。结论黄芪消渴方联合二甲双胍缓释片治疗T2DM效果显著，可改善机体胰岛功能，调节肝脏脂肪含量，值得推广。

Objective To investigate the effect of Huangqi Xiaoke Recipe combined with metformin sustained-release tablet in the treatment of type 2 diabetes mellitus （T2DM） and its effect on islet β-cell index （ HOMA-β ） , insulin resistance （ HOMA-IR） , liver fat content. Methods From November 2015 to June 2017, 90 patients with type 2 diabetes in our hospital were randomly divided into 2 groups, 45 cases each. In the control group, metformin tablets and glimepiride were used for hypoglycemic treatment. The observation group was combined with astragalus and thirst-quenching on the basis of the control group. The 12-week course was 1 course. The clinical efficacy of the two groups was compared. Results After treatment, fasting blood glucose and 2h postprandial blood glucose levels were lower in the observation group than in the control group （ P〈0.05 ） . HOMA-β was higher in the observation group than in the control group, and HOMA-IR and liver fat content were lower in the observation group than in the control group. In the control group （P〈0.05） , the total effective rate was 91.11%, in the observation group and 73.33% in the control group, with a significant difference （ P〈0.05 ） . Conclusion Huangqi Xiaoke Recipe combined with metformin sustained-release tablet is effective in treating type 2 diabetes, which can improve islet function and regulate liver fat content. It is worthy of promotion.