多囊卵巢综合征并发抑郁的危险因素分析

Related factors for complicating depression in patients with polycystic ovarian syndrome

目的 探究多囊卵巢综合征（polyeystic ovarian syndrome,PCOS）并发抑郁的危险因素。方法回顾性分析2013年8月至2016年11月于我院治疗且符合标准的142例PCOS患者的临床资料。包括人口学资料、月经情况、体征、血清激素水平、治疗情况等，采用汉密顿抑郁量表（Hamilton depression scale，HAMD）评估患者抑郁程度，并将患者分为抑郁组和非抑郁组，采用单因素矿检验和多因素Logistic回归分析探究PCOS并发抑郁的危险因素。结果 30.98％的PCOS患者出现抑郁，其中轻度抑郁28例，中度抑郁14例，重度抑郁2例。单因素X^2检验结果显示BMI Х^2=4.385，P=0.036）、不孕Х^2=8.367，P=0.004）、LH／FSH（Х^2=4.592，P=-0.032）、血清FT（X^2=5.777，P=0.016）是PCOS并发抑郁的相关因素；多因素Logistic回归分析显示BMI〉25kg／m^2（OR=12.874，95％CI：1.675-75.824，P=0.013）、不孕（OR=17.526，95％CI：1.436-94.335.P=0.008）、LH／FSH〉2（OR=7.326，95％CI：1.263-43.128，P=0.021）、血清FT异常（OR=9.724.95％CI：3.625-56.524.P=0.016）为PCOS并发抑郁的独立危险因素。结论 PCOS患者存在轻中度抑郁倾向，其中BMI〉25kg／m^2、不孕LH／FSH〉2、血清FT升高是PCOS并发抑郁的独立危险因素。

Objective To explore risk factors of depression in patients with polycystic ovarian syndrome （PCOS）. Methods 142 patients diagnosed as PCOS and meeting criterions were collected from Aug. 2013 to Nov. 2016 in our hospital. Demographic data, menstrual status, signs, serum hormone levels, treatment were collected and recorded. The degree of depression was evaluated by Hamilton Depression scale （HAMD）. They were divided into two groups： depression and non-depression group. Univariate X^2 test and multivariate logistic regression analysis were used to explore risk factors for complicating depression in patients with PCOS. Results Depression occurred in 44 patients （30.98%）, with 28 cases of mild depression, 14 cases of moderate depression, and 2 cases of severe depression. Univariate X^2 test revealed that BMI（X^2=4.385, P=0.036）, infertility （Х^2=8.367, P=0.004）, LH/FSH （Х^2=4.592, P=0.032） and serum levels of FT （Х^2=5.777, P=0.016） were factors related to depression. Multivariate logistic regression analysis revealed that BMI〉25 kg/m^2 （OR=12.874, 95% CI：1.675-75.824, P=0.013）, infertility （OR=17.526,95% CI：1.436-94.335, P=0.008）, LH/FSH〉2 （OR=7.326,95% CI：1.263-43.128, P=0.021 ） and abnormal FT（OR=9.724, 95% CI ：3.625-56.524, P=0.016） were risk factors of depression. Conchlsions Patients with PCOS have mild or moderate depressive tendencies.BMI〉25 kg/m^2, infertility, LH/FSH〉2,abnormal FT were the risk factors of depression.