糖尿病肾脏疾病生物标记物的研究进展

Progress of research on biomarkers of diabetic kidney disease

糖尿病肾脏疾病(DKD)是糖尿病常见的并发症之一,也是终末期肾病的主要原因。由于治疗手段有限,DKD的早期诊断和病程预测对于改善临床管理尤为重要。尽管蛋白尿、血肌酐等被认为是DKD早期诊断、病程评估的重要指标,但实际上它们的诊断效能非常有限。因此,亟需寻找更具诊断或预测价值的DKD生物标记物。本文就近年来DKD生物标记物的研究新进展作一综述,为诊断策略的开发提供思路。

Diabetic kidney disease（ DKD） is a one of the common complications of diabetes,and is a leading cause of end-stage renal disease. Early diagnosis and disease course prediction of DKD become crucial for clinical management improvement due to the lack of effective treatment. Although proteinuria and serum creatinine are important indicators for early diagnosis and prognosis evaluation of DKD,in fact,their diagnostic efficiency is very limited. Therefore,there is an urgent need to find more efficient biomarkers in diagnosing or predicting DKD. This article reviewed recent advances in the study of biomarkers of DKD so as to provide ideas for the development of diagnostic strategies.