2型糖尿病患者血清Semaphorin 3a与颈动脉内-中膜厚度的相关性研究

Relationship between serum semaphorin 3aand carotid intima-media thickness in patients with type 2diabetes mellitus

目的探讨T2DM患者血清Semaphorin 3a(Sema3a)与颈动脉内-中膜厚度(CIMT)的关系。方法选取T2DM患者116例,CIMT<0.9 mm为正常组(NCIMT组,n=59);CIMT≥0.9 mm为增厚组(ACIMT组,n=57)。同期选取57名健康体检者为对照(NC)组。检测各组临床生化指标。结果与NC组比较,NCIMT组及ACIMT组血清Sema3a升高[(150.00!5.69)vs(124.05±6.93)vs(85.37±4.76)ng/ml,P<0.01],NCIMT组高于ACIMT组(P<0.05);相关分析显示,血清Sema3a水平与臀围、FPG、尿素、HbA1c呈正相关(r=0.013、0.000、0.032、0.000,P<0.05或P<0.01);Logistic回归分析显示,年龄、SBP和CIMT增厚呈正相关,血清Sema3a和CIMT增厚呈负相关(P<0.05)。结论 T2DM患者血清Sema3a水平增高,是CIMT增厚的保护因素,可能与糖尿病动脉粥样硬化发展过程有关。

Objective To explore the relationship between carotid intima-media thickness（CIMT）and serum semaphorin 3 a（sema3 a）in patients with type 2 diabetes（T2 DM）. Methods A total of 116 patients with T2 DM were enrolled in this study.All the patients were divided into two groups based on the value of CIMT：normal CIMT（CIMT〈0.9 mm,NCIMT,n=59）and abnormal CIMT（CIMT≥0.9 mm,ACIMT,n=57）.Healthy individuals were enrolled as control group（NC,n=57）.Clinical and biochemical parameters were tested among the three groups. Results The levels of serum sema3 awere higher in NCIMT and ACIMT groups than in NC group [（150.00±5.69）vs（124.05±6.93）vs（85.37±4.76）ng/ml,P〈0.01）.The levels of serum sema3 awere higher in NCIMT than in ACIMT group（P〈0.05）.Correlation analysis showed that serum sema3 awas positively correlated with hip circumference（HC）,fasting plasma glucose（FPG）,UREA,and HbA1 c（r=0.013,0.000,0.032,0.000,P〈0.05 or P〈0.01）.Logistic regression analysis showed that age and systolic blood pressure（SBP）were positively related to CIMT,while sema3 awas negatively related to CIMT（P〈0.05）. Conclusion Serum level of sema3 ais increased in T2 DM.It is a protective factor for CIMT,and played an important role in the development of atherosclerosis in DM.