左西孟旦治疗慢性心力衰竭的疗效分析

Effect of Levosimendan on Patients With Chronic Heart Failure

目的探讨左西孟旦注射液治疗慢性心力衰竭（chronic heart failure, CHF）患者的疗效及安全性。方法将2016年11月-2017年10月中国人民武装警察部队总医院收治的60例慢性心力衰竭患者随机分为对照组与观察组，每组各30例。对照组给予常规抗心力衰竭治疗，观察组在对照组基础上加用左西孟旦注射液治疗。于治疗前、治疗后7d检测B型利钠肽（B-type natriuretic peptid, BNP）、左心室射血分数（lefl ventricular ejectionfraction, LVEF），并经行疗效评价。结果治疗7d后，与治疗前比较，2组BNP下降，LVEF升高，差异有统计学意义（P〈0．05）；与对照组治疗后比较，观察组BNP下降，LVEF升高，差异有统计学意义（P〈0.05）。观察者组总有效率（90．0％）高于对照组（63．3％），差异有统计学意义（P〈0．05）；治疗期间2组患者均未出现严重不良反应。结论左西孟旦可显著改善慢性心力衰竭患者的心功能，且不良反应少。

Objective To explore the curative effect and safety of levosimendan on patients of chronic heart failure （CHF）. Methods 60 patients with chronic heart failure were randomly divided into control group and observation group （30 cases in each group）.The control group was given traditional anti-CHF therapy, and observation group was given traditional anti-CHF therapy plus leosimendan injection）. The changes of B-type natriuretic peptid （BNP）and left ventricular ejection fraction （LVEF） were detected before and after 7days treatment, and curative effect of leosimendan was reviewed. Results After 7 days treatment, Compared with before treatment, the level of BNP decreased and the level of LVEF increased in two groups（P〈0.05）. Compared with after treatment of the control group, the level of BNP decreased and the level of LVEF increased in observation group （P〈0.05）. The total effective of observation group （90.0%）were higher than those of the control group （63.3%）, （P〈0.05）.The difference in incidence of adverse reactions had no statistical significance between two groups （P〉0.05）.Conclusion Levosimendan can effectively improve the cardiac function in patients with chronic heart failure.and fewer adverse reactions.