阿托伐他汀联合银杏叶对脑梗死患者脑血流参数和颈动脉粥样硬化斑块的影响

Effects of atovastatin and ginkgo biloba preparations on cerebral blood flow parameters and carotid atherosclerotic plaque indexes in patients with cerebral infarction

目的探讨阿托伐他汀辅助银杏叶对脑梗死患者颈动脉粥样硬化斑块和脑血流参数的影响。方法 235例脑梗死患者随机分为两组,对照组116例予以阿托伐他汀治疗,实验组119例在对照组治疗的基础上,加用银杏叶制剂。比较两组治疗前后颈动脉粥样硬化斑块、脑血流动力学参数变化,同时记录用药期间不良反应。结果实验组治疗后血流动力学指标RI(0.52±0.17)、PI(0.91±0.24)低于对照组,Vd(37.29±2.82)cm/s、Vs(81.33±3.58)cm/s、Vm(9.78±1.22)cm/s高于对照组(P<0.05);实验组治疗后斑块面积(0.52±0.12)cm2、CAIMT(1.26±0.17)mm低于对照组(P<0.05);两组不良反应率无统计学差异。结论阿托伐他汀联合银杏叶制剂能够促进脑梗死患者血流动力学参数表达水平的恢复,改善颈动脉粥样硬化斑块,安全性高。

Objective To investigate the effect of atovastatin and ginkgo biloba preparations on cerebral blood flow parameters and carotid atherosclerotic plaque indexes in patients with cerebral infarction. Methods Two hundred and thirty-five patients with cerebral infarction were selected in our hospital. The patients were divided into two groups according to the drug regimen. The control group（ n = 116） was treated with atovastatin while the experimental group（ n = 119） was additionally given ginkgo biloba preparations.The changes of carotid atherosclerotic plaques,cerebral hemodynamic parameters and hemorheological indexes were compared before and after treatment. Adverse reactions were also recorded. Results In the experimental group,the hemodynamic indexes RI（ 0. 52 ±0. 17） and PI（ 0. 91 ± 0. 24） were significantly lower than in the control group,while Vd（ 37. 29 ± 2. 82） cm/s,Vs（ 81. 33 ± 3. 58）cm/s and Vm（ 9. 78 ± 1. 22） cm/s were significantly higher（ P〈0. 05）. In the experimental group,the plaque area of posterior carotid atherosclerosis（ 0. 52 ± 0. 12） cm2,CAIMT（ 1. 26 ± 0. 17） mm was significantly smaller than that of the control group（ P〈0. 05）after treatment. There was no significant difference in the rate of adverse reactions between the two groups. Conclusions For patients with cerebral infarction,atovastatin combined with ginkgo biloba preparations can effectively promote the recovery of hemorheological indexes and hemodynamic parameters and improve carotid atherosclerotic plaques. This approach is quite safe.