成纤维细胞生长因子10的功能及机制进展

The research advances of function and mechanism of the role of fibroblast growth factor 10

背景成纤维细胞生长因子（fibroblast growth factor, FGF）10是FGF家族中的一员，主要表达于胚胎的上皮细胞和间质细胞、成纤维细胞以及成年的肝、肺、脑、肠等组织器官，在不同组织器官中发挥多样性的作用。目的为进一步探索FGF10的生理学功能及作用机制奠定良好的基础。内容回顾FGF10在促进肺、脂肪、心肌和前列腺、乳腺等器官的发育，以及癌症、围手术期脑卒中、心肌梗死等方面的研究进展。趋向FGF10在围手术期脑卒中的防治方面具有一定的指导意义，并为之提供新思路。

BackgroundFibroblast growth factor（FGF）10 is a member of the FGF family, mainly expressed in epithelial cells and mesenchymal cells, fibroblasts of adult liver, lungs, brain, intestines and other organs. It plays diverse roles in different organs and tissues, such as angiogenesis, promoting wound healing, participating in the process of embryo development.ObjectiveThis review will lay a good foundation for further study on the physiological function and mechanism of the role of FGF10.ContentThis paper reviews recent progresses on the role of FGF10 in development of organs in lung, fat, heart, prostate, breast and other organs and also function of FGF10 related with cancer, stroke and myocardial infarction. TrendIt would provide new ideas on the prevention and treatment of perioperative stroke to a certain extent.