IL-19在炎症性疾病中的作用机制与研究进展

Mechanisms and advances of IL-19 in inflammatory diseases

白细胞介素-19(Interleukin-19,IL-19)是近年来新发现的白细胞介素-10(IL-10)超家族的细胞因子。IL-10普遍被认为是系统性抑制炎症的细胞因子,而IL-19与IL-10序列和结构相似,因此过去认为二者具有相似的生物学活性,但随后有许多研究证明,IL-19的生物学作用与IL-10有诸多不同,并且IL-19在不同系统的疾病中尤其是炎症反应方面也具有不同作用。国内外学者就IL-19在部分炎症性疾病中的发病机制、作为潜在治疗靶点的可行性做了不少研究,现就近年来IL-19在心血管、呼吸等系统炎症性疾病中的作用机制及其研究进展做一综述。

Interleukin-19（IL-19）is a newly discovered cytokine of the interleukin-10（IL-10）superfamily.IL-10 is generally considered to be a systemic cytokine that inhibits inflammation,whereas IL-19 is similar to IL-10＇s sequence and structure,so it＇s been thought that both have similar biological activities,but many studies have shown that the biological effects of IL-19 are different from those of IL-10,and IL-19 also has different effects in different systems of diseases,especially in inflammatory response.Researchers have done a lot of research on the pathogenesis of IL-19 in some inflammatory diseases and feasibility of being apotential therapeutic target.The main goal of this review is to discuss the underlying mechanisms and research progress in cardiovascular,respiratory and other inflammatory diseases.