NT-ProBNP对心力衰竭患者再入院率的预测价值

Predictive value of NT-ProBNP in readmission rate in patients with heart failure

目的探讨氨基末端B型钠尿肽原(NT-ProBNP)对心力衰竭患者再入院率的预测价值。方法选择2016年10月至2017年10月在北京市海淀医院心内科住院治疗的心力衰竭患者186例,按照美国纽约心脏病学会(NYHA)心功能分级分为4组,分别检测患者入院24 h内,出院日,出院后1、3、6个月的NT-ProBNP水平,并跟踪收集186例患者的再入院率,分析NT-ProBNP水平对再入院率的预测价值。结果随着心功能分级从Ⅰ级到Ⅳ级,患者的NT-pro BNP水平呈现明显上升趋势;经过入院治疗后,在出院当日的NT-pro BNP水平明显低于入院24 h内水平;各组出院后1、3、6个月之间的NT-pro BNP水平差异有统计学意义(P<0.05);每组的再入院率均随时间的延长而增加;不同心力衰竭等级分组中,同一时间的入院率随着心力衰竭级别的上升而升高,各组患者的NT-pro BNP水平与再入院率呈正相关。结论 NT-ProBNP对心力衰竭患者再入院率的预测有一定价值。

Objective To analyze the value of NT-ProBNP in predicting the readmission rate of patients with heart failure. Methods One hundred and eighty-six patients with heart failure who were admitted to our department from October 2016 to October 2017 were collected. According to NYHA classification, patients were divided into four groups（class I group, class Ⅴgroup, class Ⅴ group, class Ⅴ group）. The levels of NT-ProBNP were measured within 24 hours of admission, on the day of discharge, 1 month, 3 months and 6 months after discharge, and the readmission rate was followed.Results The level of NT-pro BNP increased significantly with the increasing of heart failure level. The concentration of NT-pro BNP on the day of discharge was significantly lower than that of NT-pro BNP within 24 hours of admission. NTpro BNP was statistically significant between 1 month, 3 months and 6 months after discharge. The readmission rate of each group increased with the increasing of time. The rate of admission at the same time increased with the increase of the level of heart failure. Spearman correlation analysis indicated that NT-pro BNP level was significantly correlated with the rate of admission. Conclusion NT-pro BNP has important value for predicting the readmission rate of patients with heart failure.