清眩醒脑颗粒联合复位治疗BPPV的临床研究

Efficacy of herbal medicine Qing Xuan Xing Nao granules combined with repositioning for benign paroxysmal positional vertigo

目的观察清眩醒脑颗粒联合复位治疗良性阵发性位置性眩晕(benign paroxysmal positional vertigo,BP-PV)的临床疗效。方法将60例BPPV患者根据随机数字表法分为试验组和对照组。试验组30例,给予复位治疗加清眩醒脑颗粒口服;对照组30例,给予复位治疗加安慰剂口服,2组疗程均为1周。治疗后1周统计2组的有效率,分别于治疗前、治疗后1周和治疗后4周统计2组的眩晕残障量表评分,并观察记录2组患者的不良反应。结果治疗后1周,试验组与对照组有效率分别为96.67%和86.67%,差异无统计学意义(χ~2=0.523,P=0.470)。治疗后1周和治疗后4周,试验组和对照组的眩晕残障量表评分均较各自治疗前之评分明显降低(P<0.05),而试验组治疗后1周和治疗后4周的眩晕残障量表评分分别低于对照组同期眩晕残障量表评分(P<0.05),2组患者均无严重的不良反应。结论清眩醒脑颗粒联合复位治疗BPPV,能改善患者的心理和躯体症状,有良好的安全性。

Objective To observe the efficacy of herbal medicine Qing Xuan Xing Nao granules combined with repositioning in the treatment of benign paroxysmal positional vertigo（BPPV）. Methods Sixty patients with BPPV were divided into experimental group and control group according to random number table, 30 in each group. Patients in experimental group were treated with herbal medicine Qing Xuan Xing Nao granules and repositioning maneuvers, while patients in control group with placebo and repositioning maneuvers. Effective rates of both groups were compared one week after treatment. The dizziness handicap inventory（DHI） score were evaluated before treatment and 1 week and 4 weeks after treatment. Side effects in patients of two groups were evaluated. Results The effective rates at one week after treatment in experimental and control group were 96.67% and 86.67% respectively, with no statistically significant difference（χ^2=0.523, P = 0.470）. DHI scores at 1 and 4 weeks after treatment in experimental group or control group were lower than those before treatment in individual group（P〈0.05）; and DHI scores at 1 and 4 weeks after treatment in experimental group were respectively higher than those in control group（P〈0.05）. No significant side effect was found in patients of both groups. Conclusion Herbal medicine Qing Xuan Xing Nao granules combined with repositioning can significantly improve the treatment efficacy for benign paroxysmal positional vertigo, reducing mental and physical symptoms of patients, with good safety.