抗生素不同用药时间预防选择性剖宫产术后感染效果比较

Effect of different antibiotics medication time on the prevention of selective cesarean section postoperative infection

目的探讨预防选择性剖宫产术后感染的抗生素应用时间。方法将本院产科2015年1月至2016年6月收治的180例选择性剖宫产孕妇按数字随机表法分为两组,每组90例,观察组术前30 min一次性应用头孢呋辛钠2 g静脉滴注,对照组术前30 min及术后1~3 d每日应用头孢呋辛钠2 g静脉滴注,比较两组手术时间、术中出血量、术后住院时间、住院费用、术后最高体温和异常体温持续时间,比较两组术前、术后3 d的白细胞计数(WBC)和C反应蛋白(CRP)含量,并比较两组术后感染发生率。结果围手术期,两组手术时间、术中出血量、术后住院时间差异无统计学意义(P>0.05),观察组住院费用低于对照组,差异有统计学意义(P<0.05);两组术后最高体温、异常体温持续时间、感染发生率差异无统计学意义(P>0.05),术前、术后3 d两组WBC计数和血CRP含量差异无统计学意义(P>0.05)。结论剖宫产术前30 min一次性应用抗生素可有效预防选择性剖宫产的术后感染。

Objective To investigate the effect of different antibiotics medication time on the prevention of selective cesarean section postoperative infection.Methods One hundred and eight patients of selective cesarean delivery mothers admitted to our hospital from January,2015 to June,2016 were divided into 2 groups according to the digital random table method,with 90 cases in each group;the observation group was given 2 g intravenous drip of cefuroxime sodium for 30 min preoperative,and the control group was given 2 g intravenous drip of cefuroxime sodium for 30 min preoperative and 2 g intravenous drip per day for 1～3 d postoperative.The operation time,intra-operative blood loss,postoperative hospital time and hospital cost,the postoperative highest temperature and duration of abnormal temperature of the two groups were compared.The white blood cell count（WBC）and blood commercial rent planning（CRP）levels before operation and 3 d after operation,and the incidence of infection of the two groups after operation were compared.Results The difference between the operation time,intraoperative blood loss,postoperative hospital stay of the two groups were not statistically significant（P〉0.05）;the hospital cost of the observation group was significantly lower than that of the control group（P〈0.05）.There were no significant differences in the highest temperature,abnormal temperature duration and the infection rate of the two groups after operation（P〉0.05）;there were no significant differences in the WBC count and blood CRP levels of the two groups before operation and 3 d after operation（P〉0.05）.Conclusion One-time use of antibiotics 30 min before cesarean section operation has an effective prevention of infection after operation.