LGR5与肿瘤发生发展关系的研究进展

Research Advances on the Relationship Between LGR5 and Tumorigenesis

LGR5是一种表达于多种正常细胞和肿瘤细胞膜的膜蛋白,其与配体R-spodin结合可增强Wnt-β-catenin信号通路,导致肿瘤的进展。LGR5在维持干细胞特性中起着关键作用,可以作为肿瘤干细胞标志物。LGR5靶向治疗能显著抑制肿瘤的生长和转移。本文将通过其与肿瘤关系的研究进行综述。

LGR5 is a membrane protein expressed in many normal cells and tumor cells.The binding of LGR5 to its ligand R-spodin enhances the WNT-beta-catenin signaling pathway and leads to tumor progression.LGR5 may play a key role in the maintenance of stem cell properties,and can serve as a marker for cancer stem cells.Targeted therapy for LGR5 can significantly inhibit tumor growth and metastasis in preclinical studies.This article will review the recent studies on the relationship between LGR5 and tumorigenesis.