早产胎膜早破孕妇血清S100钙结合蛋白A12的表达

Expression of serum S100 calcium binding protein in preterm premature rupture of membrane

目的 探讨S100钙结合蛋白A12（S100A12）在早产胎膜早破致炎机制中的作用.方法 选取早产胎膜早破孕妇36例（早产胎膜早破组）,足月胎膜早破孕妇48例（足月胎膜早破组）,另选取孕28-31＋6周健康孕妇17例作为对照组.检测三组血常规、S100A12、C反应蛋白（CRP）、糖化血红蛋白（GHB）,并进行比较.结果 早产胎膜早破组S100A12明显高于足月胎膜早破组和对照组[（1193.6 ± 443.1）ng/L比（787.7 ± 482.6）和（610.5 ± 449.0）ng/L],差异有统计学意义（P〈0.01）,但足月胎膜早破组与对照组比较差异无统计学意义（P〉0.05）.在早产胎膜早破组,妊娠期糖尿病（GDM）和非 GDM 孕妇 S100A12明显高于对照组[（1225.4 ± 422.5）和（1168.2 ± 468.2）ng/L比（610.5 ± 449.0）ng/L],而且GDM孕妇明显高于非GDM孕妇,差异有统计学意义（P〈0.05）.早产胎膜早破组孕妇S100A12与CRP、中性粒细胞百分比和GHB呈正相关（r=0.236、0.222和0.378,P〈0.05或〈0.01）.结论 S100A12在早产胎膜早破伴GDM诱发绒毛膜羊膜炎的机制中存在重要意义.

Objective To study the role of serum S100 calcium binding protein （S100A12） in preterm premature rupture of membrane induced chorioamnionitis. Methods Thirty-six patients with preterm premature rupture （preterm premature rupture group）, 48 patients with term birth premature rupture （term birth premature rupture group） and 17 normal pregnant women （control group） were selected. The blood routine, S100A12, C response protein （CRP）, glycohemoglobin （GHB） levels were detected and compared. Results The S100A12 in preterm premature rupture group was significantly higher than that in term birth premature rupture group and control group： （1 193.6 ± 443.1） ng/L vs. （787.7 ± 482.6）and（610.5 ± 449.0）ng/L,and there was statistical difference（P〈0.01）;but there was no statistical difference between term birth premature rupture group and control group（P〈0.05）.In preterm premature rupture group, S100A12 levels in the gestational diabetes mellitus （GDM） and non-GDM patients were significantly higher than those in control group：（1 225.4 ± 422.5）and（1 168.2 ± 468.2）ng/L vs. （610.5 ± 449.0） ng/L, and those in GDM patients were significantly higher than those in non-GDM patients, and there were statistical differences （P〈0.05）. In preterm premature rupture group, the S100A12 showed significant positive correlation with CRP, neutral granulocyte percent and GHB （r =0.236, 0.222 and 0.378; P〈0.05 or 〈0.01）. Conclusions S100A12 would have an important role in the mechanism of preterm premature rupture of membrane combined with GDM induced chorioamnionitis.