成年血友病患者生命质量与关节健康状况的相关性研究

Correlation between quality of life and joint health status of adult hemophilia patients

目的 探讨成年血友病患者生命质量与关节健康状况的相关性.方法 选取49例成年血友病患者,分别采用成年血友病患者生命质量测评问卷（Hemo-QOL-A）和血友病关节健康评估量表（HJHS）评价生命质量和关节健康状况.结果 成年血友病患者Hemo-QOL-A评分（39.34 ± 18.97）分,HJHS评分（33.16 ± 13.17）分.Pearson相关性分析结果显示,Hemo-QOL-A评分与HJHS评分呈正相关（r=0.490,P〈0.05）,Hemo-QOL-A评分与HJHS评分的肌肉情况、关节活动度、关节摩擦音评分呈正相关（r=0.469、0.396、0.290,P〈0.05）,与HJHS评分的肿胀情况、肿胀持续时间、关节疼痛及总体步态无相关性（P〉0.05）.49例患者294个关节中,总关节异常率为82.7%（243/294）,其中肘关节异常率为72.4%（71/98）,膝关节异常率为90.8%（89/98）,踝关节异常率为84.7%（83/98）.结论 关节周围肌肉状况和关节活动度等关节健康状况不良导致血友病患者生命质量下降.

Objective To investigate the correlation between the quality of life and joint health status of adult hemophilia patients. Methods Forty-nine adult hemophilia patients were selected.The quality of life and joint health status of patients were evaluated by hemophilia-specific health related quality of life questionnaire for adults （Hemo-QOL-A） and hemophilia joint health score （HJHS）. Results The Hemo-QOL-A score of adult hemophilia patients was （39.34 ± 18.97） scores, and HJHS score was（33.16 ± 13.17）scores.The Pearson correlation analysis result showed that Hemo-QOL-A score was positively related with HJHS score （r = 0.490, P〈0.05）, and Hemo-QOL-A score was positively correlated with muscular condition,joint activity and joint friction sound score of HJHS score（r=0.469, 0.396 and 0.290; P〈0.05）. Hemo-QOL-A score was not correlated with swelling, swelling duration, arthralgia and gait of HJHS score （P〉0.05）. In 294 joints of 49 patients, the total abnormal rate of the joint was 82.7%（243/294）,the abnormal rate of the elbow joint was 72.4%（71/98）,the abnormal rate of the knee joint was 90.8%（89/98）,and the abnormal rate of ankle joint was 84.7%（83/98）.Conclusions Decreased joint health status, mainly including the surrounding muscle condition and joint mobility, results in lower quality of life in patients with hemophilia.