长链非编码RNA在非小细胞肺癌中的研究进展

Progress of long non-coding RNA in non-small cell lung cancer

肺癌是导致全世界肿瘤相关死亡的首要原因,其中超过一半的非小细胞肺癌在确诊时已经是局部晚期或远处转移,因此预后不佳.近年长链非编码RNA在肿瘤研究领域引起了极大关注,异常表达的长链非编码RNA通过不同的转录、转录后水平或表观遗传机制在非小细胞肺癌发生和发展中起重要作用.现对长链非编码RNA在非小细胞肺癌生物学中的功能和影响进行综述,尤其是其作为肿瘤生物标志物和潜在治疗靶点的临床潜在价值.

Lung cancer is the leading cause of cancer-related deaths worldwide, among which more than half of non-small cell lung cancer had been locally advanced or distant metastasis at the time of diagnosis.Therefore,it has a poor prognosis.In recent years,long non-coding RNA（lncRNA）has drawn great attention in the field of oncology.Abnormally expression of lncRNA plays an important role in the development of non-small cell lung cancer through different transcriptional, post-transcriptional or epigenetic mechanisms.This review summarizes the current literature on lncRNA in non-small cell lung cancer, introduces the functions and influences of lncRNA in the biology of non-small cell lung cancer and highlights its clinical potential value as a tumor biomarker and potential therapeutic target.