胺碘酮联合美托洛尔静脉注射治疗快速性心律失常疗效及安全性评价

Efficacy and safety evaluation of amiodarone combined with metoprolol in the treatment of tachyarrhythmias

目的:探讨和评价胺碘酮与美托洛尔静脉注射在快速性心律失常患者中的联合应用意义。方法:选取快速心律失常患者88例,采用随机数字表法将其随机分为观察组45例和对照组43例。对照组快速心律失常患者给予胺碘酮的临床药物治疗,观察组快速心律失常患者则在对照组治疗的基础上加用美托洛尔的药物联合治疗,并分别对两组患者的临床治疗情况,血压和心率变化情况,心功能变化情况及不良反应发生情况进行比较和分析。结果:与对照组相比,观察组快速心律失常患者临床治疗达到显效标准的比率80.00%(36/45)及总有效率97.78%(44/45)均明显提高,而处于无效标准的比率2.22%(1/45)则明显降低,差异均具有统计学意义(P<0.05);观察快速心律失常患者治疗后SBP(115.26±12.49)mmHg,DBP(76.22±8.71)mmHg,HR(84.83±9.57)次/min水平均明显降低,差异均具有统计学意义(P<0.05);观察快速心律失常患者治疗后EF(64.72±7.54)%,E/A(1.21±0.22)水平均明显提高,而CO(4.78±0.53)L/min水平则明显降低,差异均具有统计学意义(P<0.05);观察组快速心律失常患者心动过缓,低血压,一过性心电图恶化等不良反应的总发生率13.33%(6/45)未明显增加,差异不具有统计学意义(P>0.05)。结论:胺碘酮联合美托洛尔静脉注射对于快速性心律失常患者临床指标的改善、临床疗效的提升及应用安全性的保障均具有极其重要的价值和意义。

Objective：To probe into and analyze the clinical application significance of amiodarone combined with metoprolol in the treatment of tachyarrhythmias.Methods：88 tachyarrhythmia patients were selected in our hospital.The patients were divided into observation group and control group by random number table method.The patients with tachyarrhythmia in control group wre treated with amiodarone.The patients with tachyarrhythmia in observation group were treated with metoprolol on the basis of the control group.The clinical treatment,blood pressure and heart rate changes,changes in cardiac function and the incidence of adverse reactions of the patients in two groups were compared and analyzed.Results：Compared with control group,the tachyarrhythmia patients in observation group,the effective rate of clinical treatment was 80.00%（36/45） and the total effective rate was 97.78%（44/45）,there were increased significantly,while the inefficiency rate was 2.22%（1/45）,there was deceased significantly,the differences were significant statistically significant（P〈0.05）;the tachyarrhythmia patients in observation group after treatment,the levels of SBP were（115.26±12.49）mmHg,DBP were（76.22±8.71）mmHg,HR were（84.83± 9.57）times/min,there were decreased significantly,the differences were significant statistically significant（P〈0.05）;the tachyarrhythmia patients in observation group after treatment,the levels of EF were（64.72±7.54）%,E/A were（1.21±0.22）,there were increased significantly,while the levels of CO were（4.78±0.53）L/min,there were decreased significantly,the differences were significant statistically significant（P〈0.05）;the tachyarrhythmia patients in observation group,the overall incidence of adverse reactions was 13.33%（6/45）,included bradycardia,hypotension,transient ECG deterioration,there were not increase significantly,the differences were not significant statistically significant（P〉 0.05）.Conclusions：Amiodarone combined with metoprolol have great value and significance for the improvement of clinical indicators improvement of clinical efficacy and the application of safety protection of patients with tachyarrhythmia.