摘要
外泌体(exosome)是动物细胞在生理或病理条件下分泌到胞外的内生性纳米微囊,在疾病发生机制和药物运输载体等研究领域成为新宠。近年来发现,外泌体在人类免疫缺陷病毒1型(human immunodeficiency virus type 1,HIV-1)感染者体内能转移病毒组分和病毒相关免疫分子,与HIV-1感染密切相关。本文以外泌体介导的HIV-1感染机制为重点,围绕外泌体与HIV-1感染的关系进行综述。
Exosomes are endogenous nanoparticles secreted by cells in physiological or pathological state.It is a durably hot topic in research fields of pathology and drug carrier systems.In recent years,it has been found that exosomes can transfer viral components and virus-related immune molecules in human immunodeficiency virus type 1（HIV-1）infection.The mechanisms of exosome-mediated HIV-1 infection are reviewed in the present paper.
作者
邱勇
马晶
曾毅
QIU Yong;MA Jing;ZENG Yi(College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China;State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China)
出处
《微生物与感染》
2018年第3期171-178,共8页
Journal of Microbes and Infections
基金
国家自然科学基金(81502974)
关键词
外泌体
人类免疫缺陷病毒1型
感染
传递
Exosome
Human immunodeficiency virus type 1
Infection
Delivery
