丹参酮Ⅱ A磺酸钠联合环磷腺苷葡胺对慢性心力衰竭患者心功能和冠状动脉血流动力学的影响研究

Impact of Sulfonic Acid Sodium Tanshinone Ⅱ A Combined with Meglumine Adenosine Cyclophosphate on Cardiac Function and Coronary Hemodynamics in Patients with Chronic Heart Failure

目的探讨丹参酮ⅡA磺酸钠联合环磷腺苷葡胺对慢性心力衰竭(CHF)患者心功能和冠状动脉血流动力学的影响。方法选取2016年1月—2017年10月如皋市人民医院收治的CHF患者80例,采用随机数字表法分为对照组与观察组,每组40例。在常规治疗基础上,对照组患者给予环磷腺苷葡胺治疗,观察组患者在对照组基础上给予丹参酮ⅡA磺酸钠治疗;两组患者均连续治疗2周。比较两组患者临床疗效及治疗前后心功能指标、冠状动脉血流动力学指标,并观察两组患者治疗期间不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)比较,差异无统计学意义(P>0.05);治疗后观察组患者LVEF高于对照组,LVEDD、LVESD短于对照组(P<0.05)。治疗前两组患者舒张期峰流速(DPV)、收缩期峰流速(SPV)、时间速度积分(TVI)比较,差异无统计学意义(P>0.05);治疗后观察组患者DPV、SPV快于对照组,TVI高于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论丹参酮ⅡA磺酸钠联合环磷腺苷葡胺治疗CHF的临床疗效确切,可有效改善患者心功能和冠状动脉血流动力学,且安全性较高。

Objective To investigate the impact of sulfonic acid sodium tanshinone Ⅱ A combined with meglumine adenosine cyclophosphate on cardiac function and coronary hemodynamics in patients with chronic heart failure（CHF）. Methods A total of 80 patients with CHF were selected in the People＇s Hospital of Rugao from January 2016 to October 2017,and they were divided into control group and observation group according to random number table,each of 40 cases. Based on conventional treatment,patients in control group received meglumine adenosine cyclophosphate,while patients in observation group received sulfonic acid sodium tanshinone Ⅱ A combined with meglumine adenosine cyclophosphate;both groups continuously treated for 2 weeks. Clinical effect,index of cardiac function and coronary hemodynamic parameters before and after treatment,and incidence of adverse reactions were compared between the two groups. Results Clinical effect in observation group was statistically significantly better than that in control group（P〈0.05）. No statistically significant differences of LVEF,LVEDD or LVESD was found between the two groups before treatment（P〉0.05）;after treatment,LVEF in observation group was statistically significantly higher than that in control group,meanwhile LVEDD and LVESD in observation group were statistically significantly shorter than those in control group（P〈0.05）. No statistically significant differences of diastolic peak velocity（DPV）,systolic peak velocity（SPV）,time velocity integral（TVI）was found between the two groups before treatment（P〉0.05）;after treatment,DPV and SPV in observation group was statistically significantly faster than that in control group,respectively,meanwhile TVI in observation group was statistically significantly higher than that in control group（P〈0.05）. No statistically significant differences of incidence of adverse reactions was found between the two groups during treatment（P〉0.05）. Conclusion Sulfonic acid sodium tanshinone Ⅱ A combined with meglumine adenosine cyclophosphate has certain clinical effect in treating patients with CHF,can effectively improve the cardiac function and coronary hemodynamics.