川崎病患儿血清白蛋白/超敏-C反应蛋白对冠脉病变的预测

The predictive value of serum albumin/high sensitive C-reactive protein in the diagnosis of kawasaki disease

目的探讨川崎病患儿急性期血清白蛋白与超敏C-反应蛋白的比值(ALB/hs-CRP)对冠脉损伤的预测价值。方法采用回顾性调查方法分析2010年1月-2017年3月住院治疗的31例川崎病患儿临床资料。结果川崎病患儿急性期血清hs-CRP水平明显增高,而ALB水平及ALB/hs-CRP明显降低,与肺炎组比较P<0.05。川崎病中并发冠脉损伤组急性期血清hs-CRP增高,而ALB水平及ALB/hs-CRP降低,与冠脉正常组比较P<0.05;hs-CRP、ALB、ALB/hs-CRP与冠状动损伤的相关性比较及ROC曲线分析:相关系数和ROC曲线下面积AUC分别为:0.53、-0.47/-0.67和0.179、0.760、0.889。结论ALB/hs-CRP值更能预测川崎病并发的冠脉损伤。

Objective To investigate the ratio of serum albumin and high sensitivity C-reactive protein（ALB/hs-CRP） in children with Kawasaki disease in acute stage on the predictive value of coronary artery lesions. Methods Retrospective investigation analysis of January 2010 to March 2017 were clinical data of 31 cases of Kawasaki disease. Results The serum hs-CRP level in children with Kawasaki disease in acute stage were significantly increased,while the level of albumin/hs-CRP decreased significantly. Kawasaki disease complicated with coronary artery lesion group, serum hs-CRP increased in acute stage, and albumin/hs-CRP and albumin decreased, compared with normal coronary group（P〈0.05）. Conclusion Albumin/hs-CRP value can predict the subsequent Kawasaki disease.