超声造影在肿瘤化疗模型中诊断价值的初步探索

Diagnostic value of contrast-enhanced ultrasound in tumor model with chemotherapy

目的:探索超声造影预测乳腺肿瘤新辅助化疗疗效的价值。方法:建立裸鼠人乳腺肿瘤模型,模拟临床给药方案,在各次化疗后测量肿瘤生物学数据、超声造影数据及血管微循环指标。结果:肿瘤血管内皮生长因子受体1在化疗早期显著下降,微血管密度在第2次化疗后显著下降;超声造影上肿瘤灌注峰值强度在化疗早期显著下降,灌注达峰时间在第2次化疗后显著上升。结论:超声造影部分指标的变化与肿瘤微循环指标一致,具有深入研究价值。

Objective： To explore the value of contrast-enhanced ultrasound（CEUS） in the diagnosis of breast cancer with neoadjuvant chemotherapy. Methods： A nude mouse model of human breast cancer was established, and the clinical drug administration program was simulated. After chemotherapy, the data of tumor biology, ultrasound imaging and blood vessel microcirculation index were measured. Results： Tumor vascular endothelial growth factor receptor 1（VEGFR-1） showed a significant decrease after the early stage of chemotherapy, and the microvascular density（MVD） decreased significantly after the second chemotherapy. The peak intensity（IMAX） of tumor perfusion significantly decreased after the early stage of chemotherapy, and the time to peak（TTP） significantly increased after the second chemotherapy. Conclusion： The changes in some indexes of CEUS are consistent with the changes in some tumor microcirculation indexes, although the correlation between them has not been confirmed and needs further research.