同型半胱氨酸、脂蛋白(a)及D-二聚体联合检测在急性脑血管病中的诊断价值

Diagnostic value of homocysteine, lipoprotein(a) and D-dimer in the combination diagnosis of acute cerebrovascular disease

目的探讨同型半胱氨酸(Hcy)、脂蛋白(a)[Lp(a)]及D-二聚体(DD)联合检测在急性脑血管病中的诊断价值。方法选择我院收治的急性脑血管病患者110例为脑血管病组,另选择同期在我院体检的110例健康体检者作为对照组。检测并分析两组患者的Hcy、Lp(a)及DD水平。结果脑血管病组的血浆Hcy、Lp(a)、DD水平均高于对照组,差异有统计学意义(P<0.05)。通过Roc曲线,确定Hcy、Lp(a)、DD的最佳临界值分别为12.7μmol/L、202.5 mg/L、0.5 mg/L;Hcy、Lp(a)、DD三项联合检测的AUC高于单项检测,诊断准确率最高。结论 Hcy、Lp(a)、DD与急性脑血管病密切相关,三项指标联合检测有利于该病的早期发现和及时治疗,具有较高临床价值。

Objective To investigate the diagnostic value of combined detection of homocysteine （Hcy）, lipoprotein （a）[Lp （a）] and D-dimer （DD） in patients with acute cerebrovascular disease. Methods A total of 110 patients with acute cerebrovascular disease were selected as cerebral vascular disease group. Another 110 physical examiner who underwent physical examination during the same period were selected as the control group. The levels of Hcy, Lp （a） and DD in both groupswere detected and analyzed. Results Plasma Hcy, Lp （a） and DD levels in incerebral vascular disease group were significantly higher than those in the control group（P〈0.05）. The optimal cutoffs of Hcy, Lp （a） and DD were 12.7μmol/L, 202.5 mg/L,0.5 mg/L. The AUC of combined detection of Hcy, Lp （a）, DD was higher than that of the single detection, with the highestdiagnostic accuracy. Conclusion Hcy, Lp （a）, DD are closely related to acute cerebrovascular disease, and combined detection of three indexes is beneficial to the early detection and timely treatment, which has high value in clinic.