新疆汉族、维吾尔族和哈萨克族人群Kell血型系统抗原频率调查

Investigation on antigenic frequency of Kell blood group system in Han,Uygur and Kazak population in Xinjiang

目的:通过调查新疆汉族、维吾尔族和哈萨克族人群中Kell血型系统抗原分布情况,了解此3组人群中Kell血型的基因频率和遗传规律。方法:对就诊的1 866例患者,用抗-K和抗-k血清,试管法和抗人球蛋白检测卡,鉴定红细胞Kell血型系统抗原。结果:1 866例中汉族574例,维吾尔族1 051例,哈萨克族241例,其Kell(K/k)血型抗原频率分别是K=0.001 7、k=0.998 3;K=0.023 8、k=0.976 2;K=0.016 6、k=0.983 4,3组人群均符合Hardy-Weinberg遗传平衡法则,具有恒定性。结论:新疆汉族、维吾尔族和哈萨克族人群Kell血型差异有统计学意义,各自具有独特而稳定的遗传特征。

Objective：To investigate the antigenic distribution of Kell blood group system in Han,Uygur and Kazak nationality in Xinjiang,and know the gene frequencies and genetic patterns of Kell blood group in these three groups.Method：The antigen identification of Kell blood group system in red blood cell was carried out in 1 866 cases of our hospital using test tube method and anti-human globulin detection card with anti-K serum and anti-k serum.Result：There were 574 cases of Han nationality,1 051 cases of Uygur nationality and 241 cases of Kazak nationality in 1 866 cases.The antigenic frequency of Kell（K/k）blood group was K=0.001 7,k=0.998 3;K=0.023 8,k=0.976 2 and K=0.016 6,k=0.983 4,respectively.The three groups were consistent with the HardyWeinberg genetic balance rule and it was in constancy.Conclusion：There were significant differences among the Kell blood group of Han,Uygur and Kazak nationality in Xinjiang,and each had its own unique and stable genetic characteristics.