摘要
Small open reading frames(sORFs) are distributed over a wide variety of transcripts. sORFs encoding functional peptides have been identified in various configurations within apparently long noncoding RNAs. Many translated sORFs have been identified across mRNAs, including 5’-upstream, coding domain, and 3’-downstream. sORFs have also been found in circular RNAs, pri-miRNAs, and ribosomal RNAs. Here, we present an overview of the wide distribution of the sORFs in transcripts and their functional roles in organisms.
Small open reading frames(sORFs) are distributed over a wide variety of transcripts. sORFs encoding functional peptides have been identified in various configurations within apparently long noncoding RNAs. Many translated sORFs have been identified across mRNAs, including 5'-upstream, coding domain, and 3'-downstream. sORFs have also been found in circular RNAs, pri-miRNAs, and ribosomal RNAs. Here, we present an overview of the wide distribution of the sORFs in transcripts and their functional roles in organisms.
基金
supported by the Project Program of State Key Laboratory of Natural Medicines(No. SKLNMBZ201403)
the National Science and Technology Major Projects of New Drugs (Nos.2012ZX09103301-004 and 2014ZX09508007) in China
This project was also funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
