摘要
目的探讨注射用头孢曲松钠不良反应产生的有关原因和一般规律,以提高临床用药的安全性。方法基于中国期刊全文数据库(CNKI)下载有关注射剂不良反应的相关文献,建立不良反应数据库,通过查询得到注射用头孢曲松钠不良反应279例,并对数据进行统计与分析。结果注射用头孢曲松钠的不良反应多发生在用药后30 min内(54.8%),且B型不良反应的发生率(60.2%)最高;给药途径以静脉注射(92.1%)为主;在临床表现中,不良反应所累及的系统、器官位居前三位的是中枢及外周神经系统损伤(40.9%)、皮肤及其附件损伤(37.6%)、全身性损伤(36.2%);预后状况较好,痊愈和好转率分别为41.2%和48.7%。结论重视引起注射用头孢曲松钠发生不良反应的原因,加强用药后的监测工作,以减少和防止不良反应的发生。
Objective To discuss the correlation factors and related rules of adverse drug reaction(ADR) of Ceftriaxone sodium for injection, so as to improve the safety of clinical use of drugs.Methods Based on the CNKI download relevant literatures on the adverse reaction of injections,and establish adverse reaction database.Through the query to get a total of 279 cases of adverse reactions of Ceftriaxone Sodium for Injection,then make statistics and analysis on the above case data.Results The adverse reaction of ceftriaxone sodium for injection mostly occurred within 30 minutes(54.8%), and the incidence of b-type adverse reaction(60.2%) was the highest; intravenous injection(92.1%) was the main route for drug administration;in clinical manifestation, the systems and organs involved in adverse reactions mainly include central and peripheral nervous system damage(40.9%), skin and adnexal injury(37.6%),systemic injury(36.2%); the prognosis was better, and the cure and improvement rates were 41.2% and 48.7% respectively.Conclusion Attention should be paid to the various reasons causing ADRs of ceftriaxone sodium for injection,and measures should be taken to enhance the ADR monitoring after the medication,so to reduce and prevent the occurrence of ADRs.
作者
朱亚平
周永红
ZHU Ya-ping;ZHOU Yong-hong
出处
《中国药物经济学》
2018年第6期30-34,共5页
China Journal of Pharmaceutical Economics
关键词
注射用头孢曲松钠
不良反应
临床用药建议
Ceftriaxone sodium for injection
Adverse drug reaction
Clinical medication suggestion