赖氨葡锌颗粒辅助磷酸肌酸钠治疗小儿轮状病毒肠炎合并心肌损伤的临床疗效

Investigate the clinical effect of Lan'an Puxin Keli assisted with creatine phosphate sodium phosphate in the treatment of rotavirus enteritis with myocardial damage in children

目的探讨赖氨葡锌颗粒辅助磷酸肌酸钠治疗小儿轮状病毒肠炎合并心肌损伤的临床疗效。方法选取2017年1—12月惠州市第六人民医院收治的轮状病毒肠炎合并心肌损伤患儿60例作为研究对象,随机分为对照组和观察组,每组30例。对照组患儿在常规治疗方案的基础上应用赖氨葡锌颗粒治疗,观察组患儿在对照组治疗方案的基础上联合应用磷酸肌酸钠治疗,比较两组患者治疗前后生化指标变化及治疗效果。结果治疗前,两组患儿的心肌钙蛋白I、肌酸激酶、同工酶、乳酸脱氢酶比较,差异均无统计学意义(均P>0.05);治疗后,观察组患儿的心肌钙蛋白I、肌酸激酶、同工酶、乳酸脱氢酶改善效果明显优于对照组,差异均有统计学意义(均P<0.05);观察组患儿治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论赖氨葡锌颗粒辅助磷酸肌酸钠能够有效提高轮状病毒肠炎合并心肌损伤患儿的临床治疗效果,对改善患儿的心肌酶谱指标具有积极作用。

Objective To investigate the clinical effect of Lan＇an Puxin Keli assisted with creatine phosphate sodium phosphate in the treatment of rotavirus enteritis with myocardial damage in children. Methods A total of 60 children with rotavirus enteritis complicated with myocardial damage were selected from Hospital as the study object, and were randomly divided into observation group and control group. 30 cases in the control group were treated with Lan＇an Puxin Keli in the routine basic treatment scheme, and 30 cases in the observation group were treated with creatine phosphate sodium on the basis of the treatment plan of the control group. Results Before and after treatment, the changes of biochemical indexes and the effective rate of treatment in the two groups were compared.There was no significant difference in creatine kinase（CK）,isoenzyme（CK-MBN）and lactate dehydrogenase（LDH） between the two groups（P〉0.05）. The improvement effect of LDH index was better than that of control group（P〈0.05）. The total effective rate of treatment in the observation group was significantly higher than that in the control group（P〈0.05）.Conclusion Lan＇an Puxin Keli assisted with creatine phosphate sodium can effectively improve the clinical treatment effect of children with rotavirus enteritis and myocardial damage.