丁苯酞联合多奈哌齐对血管性痴呆患者认知功能的影响

Effect of Butylphthalide Combined Donepezil on Cognitive Function in Patients with Vascular Dementia

目的对丁苯酞与多奈哌齐联合在血管性痴呆患者治疗中的临床运用效果加以探析,并分析其对患者认知功能的影响。方法抽选深圳市光明新区人民医院神经内科于2016年3月至2017年12月收治的78例血管性痴呆患者作为研究对象,按就诊前后顺序分为联合组与单一组,单一组患者采用多奈哌齐治疗,联合组患者采用丁苯酞+多奈哌齐治疗;对两组患者治疗后的认知功能改善情况进行比较,并评价其临床治疗效果。结果联合组患者治疗的总有效率(94.9%)显著高于单一组(74.4%),差异有统计学意义(χ2=3.681,P<0.05);两组患者治疗后的语言、计算与时间定向、短程记忆、抽象四维、视结构技能、执行功能、注意与集中与治疗前相比,差异均有统计学意义(均P<0.05);治疗后,联合组患者的语言、计算与时间定向、短程记忆、抽象四维、视结构技能、执行功能、注意与集中评分均明显高于单一组,差异均有统计学意义(均P<0.05)。结论对血管性痴呆患者采用丁苯酞联合多奈哌齐治疗临床疗效显著,能有效改善患者的认知功能。

Objective To investigate the clinical effect of combination of butylphthalide and donepezil in the treatment of patients with vascular dementia and analyze its effect on cognitive function.Methods A total of 78 patients with vascular dementia admitted to our hospital from March 2016 to December 2017 were selected as subjects for the study. The patients were divided into a combination group and a single group according to the order of visits. The single group of patients received donepezil treatment. Patients taking butylphthalide ＋ donepezil treatment; The cognitive function improvement of the two groups after treatment was compared, and the clinical therapeutic effect was evaluated.Results The total effective rate after treatment（94.9%） was significantly higher in the combined group than in the single group（74.4%）. The difference was statistically significant（χ2=3.681,P〈0.05）; the language, calculation and time of the two groups after treatment Directional, short-range memory, abstract four-dimensional, visual structural skills, executive function,attention and concentration were significantly different from those before treatment in this group P〈0.05）; language, calculation and time of patients in the combined group after treatment Directional, short-range memory, abstract four-dimensional, visual structural skills, executive function, attention and concentration were significantly higher than those in the single group, and there were significant differences（P〈0.05）.Conclusion The clinical efficacy of butylphthalide combined with donepezil in treatment of vascular dementia is significant, and it can effectively improve the cognitive function of patients.