硫酸镁联合拉贝洛尔治疗重度子前期的临床疗效

Clinical effect of magnesium sulfate combined with Labe lol in the treatment of severe preeclampsia

目的探讨硫酸镁联合拉贝洛尔治疗重度子前期的临床疗效。方法选取2015年1月至2017年6月于鹤山市人民医院进行治疗的48例重度子前期患者作为研究对象,用随机数字表法将其分为试验组与对照组,每组24例。试验组患者采用硫酸镁联合拉贝洛尔进行治疗,对照组患者采用拉贝洛尔进行治疗,观察两组患者治疗前后舒张压、收缩压以及治疗效果、24 h尿蛋白以及妊娠终止时间。结果治疗前,两组患者收缩压、舒张压比较,差异均无统计学意义(均P>0.05);治疗后,试验组患者的收缩压、舒张压均明显低于对照组,差异均有统计学意义(均P<0.05)。试验组患者治疗有效率为100.0%,对照组患者治疗有效率为87.5%,差异有统计学意义(χ~2=4.364,P=0.036)。治疗前,试验组24 h尿蛋白为(2.76±0.37)g,对照组为(2.77±0.45)g,差异无统计学意义(P>0.05);治疗后试验组24 h尿蛋白为(2.52±0.42)g,对照组为(3.12±0.58)g,差异有统计学意义(P<0.05)。试验组患者妊娠终止时间与对照组相比,差异有统计学意义(P<0.05)。结论硫酸镁联合拉贝洛尔治疗重度子前期疾病效果确切,能够使患者血压控制在一定范围内,效果显著。

Objective To explore the clinical efficacy of magnesium sulfate combined with labetalol in the treatment of severe preeclampsia.Methods A total of 48 patients with severe pre-eclampsia treated at the Heshan People＇s Hospital between January 2015 and June 2017 were selected as study subjects. The two groups of patients were divided into experimental group and control group by digital method. Twenty-four patients in each group were treated with magnesium sulfate combined with labetalol in the experimental group, and were treated with labetalol in the control group. The diastolic blood pressure,systolic blood pressure, treatment effect, and 24-hour urine before and after treatment were observed in the two groups. Protein and pregnancy termination time.Results Before treatment, the difference of systolic pressure and diastolic pressure between the two groups was not statistically significant（P〉0.05）. After treatment,the systolic pressure and diastolic pressure of the patients in the experimental group were significantly lower than those in the control group, and the difference was statistically significant（P〈0.05）. In the experimental group, the effective rate was 100.0%; in the control group,the effective rate was 87.50%, and the difference was statistically significant（χ2=4.364,P=0.036）.Before treatment, the 24-hour urinary protein in the test group was（2.76±0.37） g, and the urine protein was（2.52±0.42） g in 24 hours after treatment, and the 24-hour urinary protein in the control group was（2.77±0.45） g,24 hours after treatment. The urinary protein was（3.12±0.58）g. There was a statistically significant difference between the two groups before and after treatment（P〈0.05）. There was a significant difference in the termination time of pregnancy between the experimental group and the control group（P〈0.05）.Conclusion Magnesium sulfate combined with labetalol has a definite effect on the treatment of severe preeclampsia. It can control the blood pressure of the patient within a certain range and has a significant effect.