2008—2017年六安市人民医院抗感染药物不良反应分析

Analysis on adverse reactions of anti-infection drugs in Lu'an People's Hospital from 2008 to 2017

目的分析六安市人民医院抗感染药物不良反应/事件的规律及特点,为临床合理应用提供参考。方法搜集2008年1月—2017年12月六安市人民医院上报至国家药品不良反应监测系统的543例抗感染药物不良反应/事件报告,利用回顾性分析手段对患者基本情况、抗感染药物分类、不良反应临床表现、给药途径等多方面进行分析、研究。结果 543例抗感染药物不良反应/事件报告中,男、女患者分别为271、272例;大于65岁年龄段发生率最高,占23.94%;共涉及12大类56种抗感染药物,其中不良反应例数最多的是头孢菌素类(218例,40.15%),其次是喹诺酮类(81例,14.92%);累及的器官或系统主要是皮肤及其附件(231例,42.54%),其次是消化系统(173例,31.86%);给药途径主要是静脉滴注(313例,57.64%),其次是口服(213例,39.23%)。结论六安市人民医院抗感染药物不良反应/事件的发生与药物种类,给药途径等多种因素有关,医疗机构应重视抗感染药物不良反应,加强抗感染药物的临床应用监管。

Objective To analyze the laws and characteristics of adverse anti-infection drugs reactions/events, and provide references for the promotion of rational clinical application. Methods 543 Cases of effective anti-infection drugs adverse reaction reports from January 2008 and December 2017 in Lu＇an People＇s Hospital to National ADR Monitoring Center were selected and analyzed according to the patient＇s basic situation, anti-infection drugs classification, clinical manifestations of adverse reactions, and route of administration. Results In 543 cases of adverse drug reaction/incident report, 271 cases of men and 272 cases of women were reported. Patients over the age of 65 had the highest incidences（23.94%）. There were 12 categories of 56 anti-infective agents, among which the most adverse reactions were cephalosporin（218 cases, 40.15%）, followed by quinolones（81 cases, 14.92%）. The organs or systems involved were mainly skin and accessories（231 cases, 42.54%）, followed by the digestive system（173 cases, 31.86%）. The main route of administration was intravenous drip（313 cases, 57.64%）, followed by oral（213 cases, 39.23%）. Conclusion The adverse reaction of anti-infection drug in Lu＇an People＇s Hospital is related to many factors such as drug types and route of administration. Medical institutions should pay attention to the adverse reaction of anti-infection drug and strengthen the clinical application supervision.