二仙汤加减联合精活速治疗肾阳亏虚型少弱精子症的临床观察

Clinical observation on modified Erxian Decoction combined with Jinghuosu in the treatment of oligospermia and asthenospermia with deficiency of kidney yang

目的观察二仙汤加减联合精活速治疗肾阳亏虚型少弱精子症的临床疗效。方法将105例肾阳亏虚型少弱精子症患者随机分为联合组、中药组及精活速组,每组35例。联合组予二仙汤加减联合精活速治疗,中药组以二仙汤加减治疗,精活速组予精活速治疗。各组疗程均为3个月,观察临床疗效,比较精液常规指标的变化情况。结果 (1)精活速组、中药组、联合组临床总有效率分别为62.9%、65.7%、82.9%。组间临床疗效比较,联合组明显优于精活速组(P<0.05)、亦优于中药组(P<0.05);精活速组与中药组疗效差异无统计学意义(P>0.05)。(2)治疗前后组内比较,各组精液浓度、精子成活率、a级精子比例、(a+b)级精子比例差异均有统计学意义(P<0.05)。组间治疗后,中药组与精活速组比较,精液浓度及精子成活率差异有统计学意义(P<0.05),联合组对各项指标的改善明显优于精活速组(P<0.05);联合组对各项指标的改善明显优于中药组(P<0.05)。结论二仙汤加减联合精活速治疗肾阳亏虚型少弱精子症,可显著改善患者精液质量,提高精子活力。

Objective To observe the clinical efficacy of modified Erxian Decoction combined with Jinghuosu in the treatment of oligospermia and asthenospermia with deficiency of kidney yang. Methods 105 patients of oligospermia and asthenospermia with deficiency of kidney yang were randomly divided into the combination group,Chinese medicine group and Jinghuosu group,35 cases in each group. The combination group was treated with modified Erxian Decoction plus Jinghuosu,the Chinese medicine group was treated with modified Erxian Decoction and the Jinghuosu group was treated with Jinghuosu,with a course of 3 months.The clinical efficacy was observed,and the changes on semen routine indicators were compared. Results（1）The clinical total effective rates were 62.9% in the Jinghuosu group,65.7% in the Chinese medicine group and 82.9% in the combination group. The clinical efficacy of the combination group was significantly better than that of the Jinghuosu group（ P〈0.05） and the Chinese medicine group（ P〈0.05）. There was no statistically significant difference on the efficacy between the Jinghuosu group and Chinese medicine group（ P〉0.05）.（2）In all groups,there were statistically significant differences on the semen concentration,sperm survival rate,proportion of a-grade sperm and proportion of（ a ＋b）-grade sperm between treatment before and after（ P〈0.05）. After treatment,there were statistically significant differences on the semen concentration and sperm survival rate between the Chinese medicine group and Jinghuosu group（ P〈0.05）. The improvement on all the indicators in the combination group was significantly better than that in the Jinghuosu group（ P〈0.05） and the Chinese medicine group（ P〈0.05）.Conclusion The modified Erxian Decoction combined with Jinghuosu can significantly improve the semen quality and sperm motility in the treatment of oligospermia and asthenozoospermia with deficiency of kidney yang.