上海地区胆囊结石病的流行病学调查

Epidemiology of gallbladder stone disease in Shanghai

目的:研究上海地区居民胆囊结石病(以下简称胆石病)的患病情况及其相关的危险因素。方法 :2010年8月至2011年7月期间,对上海三个区部分20~79岁自然人群15 256人进行横断面调查。其中男8 617人,女6 639人。使用问卷调查、体格检查和实验室生化分析等方法收集参加者相关临床数据。胆囊疾病采用空腹B超检查确诊。采用t检验和Logistic逐步回归分析与胆石病相关的危险因素。结果:(1)胆石病总体患病率为7.02%,女性(8.10%)略高于男性(6.19%)(P<0.05)。不论性别,胆石病的患病率随年龄递增(P<0.05)。(2)胆囊总体切除率为2.48%,女性(3.42%)是男性(1.75%)的约2倍(P<0.05),也随年龄递增(P<0.05)。(3)Logistic逐步回归分析显示,女性、高龄、脂肪肝、胆石病家族史、高血压、体质量指数增加为胆石病相关的危险因素。结论:本研究调查显示,当前上海地区人群总体胆石病患病率为7.02%,胆囊切除率为2.48%。性别、年龄、脂肪肝、胆石病家族史、高血压和体质量指数与胆石病发生密切相关。

Objective To investigate the prevalence of gallbladder stone disease（GSD） in Shanghai and analyze the risk factors associated with GSD.Methods The cross-section survey was carried out from August 2010 to July 2011.We enrolled 15 256 habitants in three districts of Shanghai（8 617 male and 6 639 female）,aged between 20-79 years old.The relevant clinical data of the subjects were collected by questionnaire,physical examination and biochemical analysis.GSD was diagnosed by type-B ultrasonography.T test and Logistic stepwise regression were performed to analyze the risk factors associated with GSD.Results（1） The prevalence of GSD was 7.02% in this survey,which was slight higher in females than in males（8.10% vs 6.19%,P〈 0.05） and increased with age（P 〈0.05）.（2） The rate of cholecystectomy was2.48% in total,almost twice in females than in males（3.42% vs 1.75%,P〈0.05）,and increased with age as well（P〈0.05）.（3） Logistic stepwise regression analysis showed that female,older,presence of fatty liver disease,family history,hypertension and increased body mass index（BMI） were the risk factors for GSD.Conclusions Our survey showed that the prevalence of GSD was 7.02% and the cholecystectomy rate was 2.48% in Shanghai population.Gender,age,fatty liver disease,family history,hypertension and BMI were the risk factors associated with GSD.