直肠癌的复发和转移与血脂、CEA、CA199的关系

Relationship between recurrence and metastasis of rectal cancer and blood lipids, CEA and CA199

目的探讨直肠癌的复发和转移与血脂、CEA、CA199的关系。方法回顾性分析于2016年4月~2017年4月期间在我院进行治疗的100例直肠癌患者作为本次研究对象,通过对所有患者行根治手术治疗,对患者在手术之后的肿瘤复发和转移情况,完成CEA以及CA199的检测,分析对其检测的诊断检测价值所在。结果在本次研究中,患者中无复发和转移、局部性的复发和腹腔部位及远处发生转移的血脂、CEA、CA199的检测水平相较,腹腔部位以及远处发生转移的患者血脂、CEA、CA199检测水平,均高于无复发和转移以及局部复发的患者,相较具有统计学差异(P<0.05);所检测CEA水平在局部的复发和腹腔阳性检测率为86.39%、腹腔、远处发生转移的阳性检测率为88.91%,检测CA199水平在局部复发的阳性检测率为72.74%,在腹腔、远处发生转移的阳性检测率则为79.68%。结论通过对直肠癌患者检测CEA、CA199的检测水平展开本次研究,发现通过检测CEA以及CA199对于直肠癌患者的病症术后复发和转移,具有显著的诊断意义及价值,可以有效的作为当前临床医学中直肠癌患者行根治术之后发生复发和转移的可靠性参考依据,具有临床推广意义。

Objective To investigate the relationship between the recurrence and metastasis of rectal cancer and blood lipids, CEA and CA199. Methods One hundred cases of rectal cancer who were treated in our hospital from April 2016 to April 2017 as the object of this study were retrospective analyzed. All patients were treated with radical operation, the tumor recurrence and metastasis of the patients after the operation was observed, the detection of CEA and CA199 were completed, and the diagnostic value of the detection was analyzed. Results In this study, the levels of blood lipid, CEA, and CA199 of patients with no recurrence or metastasis or local recurrence were compared with those of patients with abdominal and distant metastasis, the levels of blood lipid, CEA, and CA199 of patients with abdominal and distant metastasis were significantly higher than those of patients with no recurrence or metastasis or local recurrence, with significant differences（P〈0.05）. The detection rate of CEA level in local recurrence and abdominal cavity was 86.39%. The positive detection rate of abdominal and distant metastasis was 88.91%. The positive detection rate of CA199 level in local recurrence was 72.74%, and the positive detection rate of metastasis in abdominal cavity and distant was 79.68%. Conclusion By testing the detection level of CEA and CA199 in rectal cancer patients, it is found that the detection of CEA and CA199 has significant diagnostic significance and value for the recurrence and metastasis of patients with rectal cancer after operation. It can be effective as the recurrence and metastasis of rectal cancer patients after radical resection in current clinical medicine. The reliability reference is of clinical significance.