血清骨保护素水平联合传统心血管危险因素对早发冠心病患者的预测作用

Predictive effect of serum osteoprotegerin levels combined with traditional cardiovascular risk factors on patients with premature coronary heart disease

目的探究早发性冠心病患者的血清骨保护素(OPG)水平变化意义,以及其发病危险因素。方法本次研究择取我院冠心病患者共105例参与研究,所有患者的入院时间区间均为2016年4月~2017年10月,根据患者的年龄要素(男性年龄≤55岁,女性年龄≤65岁)将其分为早发组和晚发组,其中早发组患者62例,晚发组43例,另择取同期来我院进行健康体检的健康者50例作为对照组。检测三组研究对象的血清OPG水平,分析早发冠心病与OPG水平的关系,同时记录三组研究对象的年龄、性别等基本信息,以及患者生活习惯及疾病史,分析疾病危险因素。结果经比较,冠心病患者和健康者、早发组与晚发组8个疾病危险因素中,饮酒史及BIM指数在两次对比中均无统计学意义(P>0.05),剩余6个因素的统计学数据在两次比较中均有统计学意义(P<0.05)。而冠心病与健康者OPG水平以及hs-CRP水平也有统计学意义(P<0.05),上述两项指标在早发组和晚发组中无统计学意义(P>0.05)。经比较,血清OPG水平与冠心病发病呈正比。结论血清OPG水平的变化可真实有效的反映出冠心病患者的病情进展和演变,而早发冠心病的发病危险因素较多,包括性别、冠心病家族史、吸烟史等。

Objective To explore the significance of serum osteoprotegerin（OPG） level and its risk factors in patients with premature coronary heart disease. Methods In this study,105 patients with coronary heart disease in our hospital were selected to participate in the study.The admission time interval of all patients was from April 2016 to October 2017.According to the age factors of the patients（male age 55 and below,women aged 65 years or younger） were divided into early onset group（62 cases） and late onset group（43 cases）.In addition,50 healthy persons who came to our hospital for physical examination at the same time were selected as control group.The serum OPG levels of the three groups were measured,and the relationship between early onset coronary heart disease and OPG level was analyzed.At the same time,the basic information of age,sex,life habits and disease history of the three groups were recorded,and the risk factors of disease were analyzed. Results Among the 8 risk factors of coronary heart disease（CHD） patients and healthy persons,early onset group and late onset group,There was no significant difference in alcohol consumption history and BIM index between the two groups（P〈0.05）,and the statistical data of the remaining 6 factors were statistically significant in the two comparisons（P〈0.05）.The levels of OPG and hs-CRP in patients with coronary heart disease and healthy subjects also had statistical significance（P〈0.05）.There was no significant difference between the two indexes in early onset group and late onset group（P〈0.05）.By comparison,the serum OPG level was in direct proportion to the incidence of coronary heart disease. Conclusion The changes of serum OPG level can reflect the progression and evolution of coronary heart disease patients,but the risk factors of early onset coronary heart disease include sex,family history of coronary heart disease,smoking history and so on.