血栓靶向递药系统研究进展

Research Progress of Thrombus Targeted Drug Delivery System

血栓栓塞性疾病已经成为继肿瘤之后又一个严重威胁人类健康的杀手。临床溶栓药物经过几十年的发展依然不能避免出血等不良反应的发生。针对这一难题,近年来研究者开展了血栓的靶向递药研究,并取得了颇多成果。多项研究表明,血栓靶向递药可使药物富集在血栓部位,并能有效降低出血等不良反应。本文就血栓靶向递药策略中的磁靶向、主动靶向、仿生靶向等三个方面,简要综述其研究进展及靶向性能评价方法。

Thrombosis disease has been another serious threat to human health after cancer. The development of clinical thrombolytic drugs for decades still cannot avoid the substantial hemorrhagic risks and other side effects. In recent years, many achievements have been made in research of targeting thrombus vectors. Many studies have shown that the thrombus targeted drug delivery system can achieve the aim of accumulation at the thrombus and effectively reduce side effects such as hemoiThage. In this paper, three aspects of magnetic targeting, active targeting, biomimetic targeting in targeted delivery strategy of thrombus are briefly reviewed. Sufficient understanding of these mechanisms will help us to design more efficient thrombus-targeting drug delivery system to address the challenges encountered in targeted drug delivery systems for thrombosis disease. Molecular imaging technique provides a noninvasive imaging method of thrombus and plays a significant role in prevention and treatment. So, the progress of the research and the evaluation methods of target performance are briefly reviewed. There are still many problems in the currently studied thrombustargeting drug delivery system, and the biomimetic thrombus-targeting drug delivery system will have a broad application prospect.