卡马西平联合丙戊酸钠治疗额叶癫痫对减轻脑损伤的作用分析

Effect of Carbamazepine combined with sodium valproate on reducing brain injury in treatment of frontal lobe epilepsy

目的探讨卡马西平联合丙戊酸钠治疗额叶癫痫对减轻脑损伤的作用。方法采用前瞻性研究方法,选取2013年8月-2016年3月在该院进行诊治的额叶癫痫患者84例。根据信封随机抽签原则分为观察组与对照组各42例,对照组给予卡马西平治疗,观察组给予卡马西平联合丙戊酸钠治疗,都治疗观察3个月,记录两组预后情况。结果观察组与对照组的总有效率分别为97.6%和85.7%,两组比较差异有统计学意义(P<0.05),观察组高于对照组。两组治疗后的癫痫发作次数及持续时间与治疗前比较,差异有统计学意义(P<0.05),治疗后少于治疗前;治疗后观察组与对照组癫痫发作次数及持续时间比较,差异有统计学意义(P<0.05),观察组少于对照组。观察组治疗期间的头痛、脱发、耳鸣、嗜睡等不良反应发生率为14.3%,对照组为16.7%,两组比较差异无统计学意义(P>0.05)。观察组治疗后的P300潜伏期及波幅分别为(322.53±26.39)ms和(15.78±5.20)μV,而对照组分别为(339.29±31.42)ms和(14.29±4.29)μV,观察组与对照组比较差异有统计学意义(P<0.05)。结论卡马西平联合丙戊酸钠治疗额叶癫痫能促进临床症状的改善,提高治疗疗效,且不增加不良反应的发生,促进恢复神经电生理功能,从而减轻脑损伤。

Objective To investigate the effect of Carbamazepine combined with sodium valproate on reducing brain injury during treatment of frontal lobe epilepsy. Methods Using a prospective study method, 84 patients of frontal lobe epilepsy diagnosed and treated in our hospital from August 2013 to March 2016 were selected. According to the random drawing principle of envelopes, the patients were equally divided into observation group and control group with 42 in each group. The control group was given Carbamazepine treatment, and the observation group was given Carbamazepine combined with sodium valproate treatment, the treatment courses were 3 months. The outcomes in the two groups were recorded. Results The total effective rate of the observation group and the control group was 97.6% and 85.7% respectively, the difference was significant（P〈0.05）. The frequency and duration of epilepsy after treatment in the two groups significantly decreased compared to those before treatment（P〈0.05）. After treatment, the frequency of seizure in the observation group was significantly lower than that in the control group, and the duration of seizure was significantly shorter than that in the control group（P〈0.05）. The total incidence of adverse reactions including headache, hair loss, tinnitus and drowsiness during treatment was 14.3% in the observation group and 16.7% in the control group without a significant difference between the two groups（P〉0.05）. The P300 latency and amplitude after treatment were（322.53 ± 26.39） ms and（15.78 ± 5.20） μv respectively in the observation group, and（339.29 ± 31.42） ms and（14.29 ± 4.29） μv in the control group, there were significant differences（P〈0.05）. Conclusions In the treatment of frontal lobe epilepsy, Carbamazepine combined with sodium valproate can improve clinical symptoms, improve the curative effect and does not increase of the occurrence of adverse reactions. It can promote the recovery of neural electrophysiological function, thus reduce brain injury.