自身免疫性甲状腺炎与乳腺癌关系的Meta分析

A Meta analysis on relationship between autoimmune thyroiditis and breast cancer

目的通过收集整理相关数据明确自身免疫性甲状腺炎与乳腺癌关系。方法通过计算机检索Pub Med、Cochrane图书馆、Embase、谷歌学术等英文数据库,检索时间截至2017年5月15日有关自身免疫性甲状腺炎与乳腺癌相关的文献,提取相关数据并用Stata 12.0软件进行统计分析。结果共纳入9篇横断面研究(累计样本量1 325例),经Meta分析,显示甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)对乳腺癌的作用合并效应Ol^R值分别为2.66(95%CI:1.93,3.68)、2.30(95%CI:1.67,3.18),差异有统计学意义。结论乳腺癌患者中血清TPOAb和TGAb高于健康者。

Objective To summarize and analyze the available data on relationship between autoimmune thyroiditis and breast cancer. Methods The relevant studies were collected by searching databases of Pub Med, Cochrane Library, Embase and Google Scholar up to May 15, 2017. The relevant data were extracted and the statistical analyses were conducted by Stata 12.0 software. Results Of 3,059 identified studies, 9 were eligible and were included in our analyses（including 1,325 participants）. There was a significant evidence of an increased risk of breast cancer in the patients with autoimmune thyroiditis [for thyroid peroxidase antibody, O^R = 2.66, 95% CI（1.93, 3.68）; for thyroglobulin antibody, O^R = 2.30, 95% CI（1.67, 3.18）]. Conclusions The present results indicated that the serum levels of thyroid peroxidase antibody and thyroglobulin antibody are significantly higher in patients with breast cancer than in healthy controls.