血清D-二聚体和肠道屏障功能指标在宫颈癌中的临床意义

Clinical significance of serum D-dimer and gut barrier function in cervical cancer

目的探讨血清D-二聚体和肠道屏障功能指标在宫颈癌中的临床意义。方法应用紫外线分光光度法检测69例宫颈癌患者血清D-二聚体水平和肠道屏障功能指标(包括D乳酸、细菌内毒素、二胺氧化酶),分析两者与宫颈癌国际妇产科联盟(FIGO)分期的关系。结果不同FIGO分期的宫颈癌患者,其血清D-二聚体、D乳酸水平差异均有统计学意义(均P<0.05);细菌内毒素、二胺氧化酶水平差异均无统计学意义(均P>0.05)。结论宫颈癌患者D-二聚体、D乳酸水平与FIGO分期有关,可指导临床辅助诊断。

ObjectiveTo investigate the clinical significance of serum D-dimer and gut barrier function in malignant cervical tumors.Methods The serum D-dimer and gut barrier function（D-lactic acid,bacterial endotoxin and diamine oxidase）were detected by ultraviolet spectrophotometry in patients with cervical cancer.The relationship of cervical cancer FIGO stage with serum D-dimer and gut barrier function was analyzed.Results The serum D-dimer level was significantly correlated with the FIGO stage of cervical cancer,and serum D-lactate level,squamous cell carcinoma antigen levels in patients（all P〈0.05）,and not correlated with the menopause status and the treatment methods of the patients.Conclusion The serum D-dimer and D-lactate levels is correlated with FIGO stage of cervical cancer,which may have clinical diagnostic value.