体细胞克隆猴的诞生及展望

The born and future prospect of the cloned monkeys

小鼠和人之间巨大的物种差异使得目前大多数利用小鼠作为研究对象获得的研究成果不能被直接用于人类疾病的临床治疗,而伦理的限制和取材的困难又往往使得直接以人为研究对象变得不现实。因此作为与人类最为相近的物种,非人灵长类正逐渐成为研究人类自身相关问题的一个重要突破口。利用体细胞核移植技术诞生的克隆猴"中中""华华"不仅为灵长类是否能被克隆画上了句号,同时也为人类疾病研究开辟了一条新的途径。

Currently,researchers apply mouse as the ideal model for human disease researches. Many,if not most of the research fruits,however,cannot be transferred to human clinical application due to huge species differences. On the other hand,ethic issues and difficulties on obtaining human materials barrier the way of doing direct research on human. These obstacles put non-human primates,which resembles with human the most,as a better model species than mouse for understanding human. The born of cloned monkeys ＂Zhongzhong＂and ＂Huahua＂by somatic cell nuclear transfer not only closure the wide range doubt on whether primate can be cloned,but set up a milestone for human disease researches.