真菌中COP9信号复合体的研究进展

Research advances in the COP9 signalosome in fungi

泛素连接酶(CRLs)主要通过泛素蛋白酶体途径来调控信号转导、转录、细胞增殖、生理节律、细胞发育等多种生化过程。COP9信号复合体(CSN)是真核细胞内高度保守的多亚基蛋白复合物,其主要功能是调控泛素相关的蛋白降解。高等真核生物缺失任何一个CSN亚基都会使突变株在发育早期致死,但真菌的CSN亚基缺失突变株能够存活,因此真菌成为研究CSN的系统进化、结构组成及生物学功能的理想材料。着重介绍了真菌中CSN的亚基组成、生物学功能及研究展望,为真菌及其他真核生物中CSN的功能研究提供一定的参考数据。

Cullin-RING E3 ubiquitin ligases（ CRLs） play important roles in regulating a wide range of processes,such as signal transduction,transcription,cell cycle progression,circadian rhythm,and development,via the ubiquitin-proteasome pathway. The COP9 signalosome（ CSN） is a highly conserved multi-subunit protein complex that controls ubiquitin-dependent protein degradation in eukaryotes. Unlike higher eukaryotes,fungi can survive without any CSN subunit,making fungi become perfect materials for the study of CSN in phyletic evolution,structural composition and biological functions. This review provides recent progress of subunit composition,biological functions and research prospects of CSN in fungi for understanding the function of CSN in fungi and other eukaryotes.