坍塌反应调节蛋白2在膀胱尿路上皮癌中的表达及其与预后的相关性

Expression of collapsin response mediator protein 2 in bladder urothelium carcinoma and its clinical significance

目的:研究坍塌反应调节蛋白2(CRMP2)在非肌层浸润性膀胱尿路上皮癌(NMIBC)中的表达及临床意义.方法:免疫组化检测130例NMIBC石蜡切片组织中CRMP2表达水平,分析其与临床病理指标的关系,通过生存分析,探讨其与肿瘤复发、进展及生存时间的相关性.单因素和多因素分析探究CRMP2是否具有独立预测作用.结果:膀胱癌组织CRMP2表达水平与肿瘤分级、复发、进展正相关(P<0.05),与年龄、性别、手术方式以及肿瘤大小无明显相关性(P>0.05).CRMP2高表达患者复发率、肿瘤进展率和死亡率明显高于低表达患者(P<0.05).单因素分析和多因素分析显示,CRMP2是患者术后复发(P=0.021,HR:2.72,95%CI:1.97,3.39)和进展的独立危险因素(P=0.021,HR:2.99,95%CI:1.93,4.61).结论:CRMP2既是NMIBC促癌因子,又是NMIBC预后不良的独立危险因素.

Objective：To investigate the expression and clinical significance of collapsin response mediator protein 2（ CRMP2） in patients with non-muscle invasive bladder urothelium carcinoma（ NMIBUC）. Methods： The expression of CRMP2 in tissue sections was determined using immunohistochemistry in 130 cases of patients with NMIBUC. Correlation between CRMP2 expression and clinicopathologic characteristics were analyzed. Kaplan-Meier survival analysis was utilized to discuss the influence of CRMP2 on recurrence-free survival（ RFS）,progression-free survival（ PFS） and overall survival（ OS）. Univariate and multivariate analysis were used to identify the independent risk factor of RFS and OS. Results： The expression of CRMP2 positively correlated with tumor grade,recurrence and progression（ P〈 0. 05）,but showed no significant correlation with age,gender,surgicalprocedure and tumor size（ P 〉0. 05）. Higher CRMP2 expression was significantly correlated with shorter RFS,PFS and OS（ P〈 0. 05）. Univariate and multivariate analysis identified CRMP2 as an independent risk factor of RFS（ P = 0. 021; HR = 2. 72,95% CI： 1. 97,3. 39） and OS（ P = 0. 021;HR = 2. 99,95% CI： 1. 93,4. 61）. Conclusion： CRMP2 is an oncogenic factor as well as an independent risk factor for poor prognosis in NMIBUC.