人绒毛膜促性腺激素注射日血清孕酮水平与妊娠结局的关系的研究

Study on the relationship between serum progesterone level and pregnancy outcome in human chorionic gonadotropin injection

目的探讨人绒毛膜促性腺激素注射日血清孕酮水平与妊娠结局的关系。方法回顾性分析2015年1月-2017年3月在山西医科大学第一医院生殖中心接受常规体外受精-胚胎移植治疗(IVF-ET)的436例新鲜周期,探讨孕酮水平与妊娠结局的关系。结果当以1.0、1.5、2.0及2.5为截断值时,高孕酮组h CG日血清E2值、获卵数、MⅡ卵数、正常受精数、2PN卵数及胚胎数高于低孕酮组,高孕酮组妊娠率低于低孕酮组,差异均有统计学意义(P≤0.05);当以1.0、1.5及2.0为截断值时,高孕酮组优质胚胎数高于低孕酮组,差异具有统计学意义(P≤0.05)。结论 h CG注射日血清P水平升高可引起IVF-ET的妊娠率下降,对受精率、优质胚胎率无影响,可能主要通过降低子宫内膜的容受性而影响妊娠结局。

Objective：To explore the relationship between serum progesterone level and pregnancy outcome in human chorionic gonadotropin injection. Methods：A retrospective analysis in January 2015-March 2017 in the first hospital of Shanxi Medical University reproductive center to accept conventional in vitro fertilization-embryo transfer（IVF-ET）treatment of 436 cases of fresh cycle,to discuss the relationship between progesterone level and pregnancy outcome. Results：When the 1.0,1.5,2.0,and 1.0 for cutoff value,high progesterone group of h CG day serum E2 values,a number of eggs,MⅡ egg number,the number of normal fertilization,the number 2 PN egg embryo and higher than that of low progesterone group,high progesterone pregnancy rate is lower than low progesterone group,the difference had statistical significance（P≤0.05）;When the truncation value was reached in 1.0,1.5 and 2.0,the high number of high-quality embryos in the high progesterone group was higher than the low progesterone group,and the difference was statistically significant（P≤0.05）. Conclusion：h CG injection day serum P levels can cause IVF-ET the pregnancy rate of decline,no effect for fertilization rate,high quality embryo rate,may mainly by reducing the receptive endometrium and pregnancy outcome.