男性患者饮酒、吸烟对体外授精-胚胎移植结局的影响

Effects of alcohol and cigarette smoking consumption on the outcome of IVF-ET

目的探讨以体外受精-胚胎移植(IVF-ET)技术助孕的男性患者其饮酒、吸烟等不良生活方式对胚胎实验室结果和临床结局的影响。方法回顾性分析IVF-ET助孕治疗中病因为不明原因的115个周期的患者资料,纳入标准为男方精液检查参数正常的病例。按男性患者是否吸烟和或饮酒分为4组,对照组、吸烟组、饮酒组和吸烟饮酒组。分别对4组中女方一般资料、男方精液参数和正常受精率、卵裂率、可利用胚胎率和临床妊娠率进行统计学分析。结果饮酒组的临床妊娠率在4组中最低,与对照组和吸烟组相比有统计学差异(P<0.01)。吸烟和饮酒组患者的正常受精率和可利用胚胎率在4组中最低,与对照组和吸烟组相比有统计学差异(P<0.01)。结论男性患者吸烟、饮酒等不良生活方式可能会影响IVF-ET患者的胚胎质量和临床妊娠率。

Objective：To evaluate the impact of alcohol intake and cigarette smoking on the outcome of in vitro fertilizationembryo transfer（IVF-ET）. Methods：This study included 115 male infertile patients with normal range of sperm conventional parameters but with unexplained infertility in assisted reproductive technologies programme. The whole lot was divided into four groups：control（nonalcoholic and nonsmoker patients）,alcohol group,smoking group and alcohol-smoking group. To compare the normal fertilization rate,cleavage rate,embryo utilization rate and clinical pregnancy rate in four groups. Results：The clinical pregnancy rate of alcohol group is lowest in four groups. The normal fertilization rate and embryo utilization rate is lowest in four groups. Conclusions：Alcohol intake and cigarette smoking can negative impact the outcome of IVF-ET calling in need by urgency to change the lifestyle behavior.