畸形精子症患者精子DNA碎片与MTHFR C677T基因多态性的相关性研究

Association study of sperm DNA fragmentation with MTHFR C677T polymorphism in teratozoospermia

目的探讨畸形精子症患者DNA碎片与MTHFR C677T基因多态性的相关性。方法实验组为45例畸形精子症患者,对照组为正常生育的健康男性88例,检测精子的DNA碎片率和MTHFR C677T基因多态性分布的关系。结果两组比较精子DNA碎片率差异有统计学意义(P<0.05),而MTHFR C677T基因型的分布频率差异不显著无统计学意义(P>0.05)。结论畸形精子症患者的DNA碎片率与MTHFR基因C677T多态性分布无相关性,MTHFR C677T基因多态性可能不是造成畸形精子症患者的DNA碎片率高的危险因素。

Objective：To investigate the association of sperm DNA fragmentation with MTHFR C677 T polymorphism in teratozoospermia. Methods：The experimental group included 45 males with teratozoospermia. The control group included 88 fertile males with sperm quality and normal fertility. To analyze the sperm DNA fragmentation and the frequency of MTHFR C677 T genetic polymorph in the two groups. Results：We found a significant difference in DNA fragmentation of sperm between the two groups（P〉0.05）.There was no significant difference in the distribution of the MTHFR C677 T genotypes between experimental group and control（P〉0.05）. Conclusion：There was no significant association between sperm DNA fragmentation and MTHFR C677 T polymorphism in teratozoospermia. So the MTHFR C677 T gene polymorphism was not the risk factors for sperm DNA fragmentation in teratozoospermia.