胰岛素样生长因子-2在不同期别宫颈癌中的表达及意义

Expressions and significance of insulin-like growth factor-2 in different stages of cervical cancer

目的检测胰岛素样生长因子-2(IGF-2)在宫颈癌组织中的表达水平,分析其在不同期别宫颈癌中的表达及意义。方法选取2013年1月-2017年1月宜宾市第一人民医院收治的不同期别宫颈癌患者110例作为宫颈癌组;另选取同期该院收治的因良性疾病行子宫切除术的患者110例作为对照组。分别对两组患者宫颈组织石蜡标本进行收集,采用免疫组织化学SP法检测IGF-2在两组组织标本中的表达水平。结果宫颈癌组IGF-2蛋白阳性表达率明显高于对照组,差异有统计学意义(P<0.05);在不同期别宫颈癌中,IGF-2蛋白在临床分期Ⅱ期、低分化组织中及有淋巴结转移组织中的阳性表达率均显著升高,差异有统计学意义(P<0.05);但IGF-2蛋白在不同病理类型组织中的表达率比较,差异无统计学意义(P>0.05)。结论宫颈癌组织中IGF-2在不同期别宫颈癌中的表达量均较高,IGF-2蛋白在临床分期Ⅱ期、低分化组织及有淋巴结转移组织中的阳性表达率较高,IGF-2蛋白的阳性表达在宫颈癌发生发展过程中起到一定的促进作用。

Objective To detect the expression level of insulin-like growth factor-2 （IGF-2） in cervical cancer, and analyze the ex- pressions and significance in different stages of cervical cancer. Methods A total of 110 patients with different stages of cervical cancer treated in the First People＇s Hospital of Yibin from January 2013 to January 2017 were selected as cervical cancer group, and 110 patients with benign diseases treated by hysterectomy in the hospital during the same period were selected as control group. Paraffin-embedded cervi- cal tissue samples in the two groups were collected. Immunohistochemical SP method was used to detect the expression levels of IGF-2 in the two groups. Results The positive expression rate of IGF-2 protein in cervical cancer group was statistically significantly higher than that in control group （ P〈0. 05 ） . The positive expression rates of IGF-2 protein in cervical cancer patients of clinical stage Ⅱ, low differentiation, and lymph node metastasis increased significantly （ P〈0. 05 ） . There was no statistically significant difference in the positive expression rate of IGF-2 protein among cervical cancer patients of different pathological types （ P〉0. 05 ） . Conclusion The expression levels of IGF-2 in different stages of cervical cancer are high, the positive expression rates of IGF-2 protein in cervical cancer patients of clinical stage Ⅱ , low differentiation, and lymph node metastasis are high, the positive expression of IGF-2 protein can promote the oncogenesis and development of cervical cancer to a certain extent.