亮氨酸富集蛋白LGI1在癫痫发生中的作用及机制

The Roles of Leucine Enriched Protein LGI1 in the Occurrence of Epilepsy

LGI1在中枢神经系统中具有多种生理和病理作用。LGI1可以调节神经胶质瘤的发生和发展,对大脑分层和小脑发育具有重要的调控作用,还能通过离子通道调节细胞兴奋性。LGI1可以结合细胞膜上的跨膜受体,改变神经递质谷氨酸的释放,并影响癫痫的发病过程。总体来说,LGI1在中枢神经系统中的作用机制仍有待阐明。该文将从介绍颞叶癫痫入手,简要综述LGI1在癫痫相关疾病中的最近进展,并讨论可行的治疗手段。

Leucine-rich glioma inactivated 1（LGI1） has a variety of physiological and pathological roles in the central nervous system. LGI1 can regulate the occurrence and development of glioma, modulate the development of cortical lamination and cerebellar foliation, and affect neuronal excitability through ion channels. It also combines transmembrane receptors on neuronal surface to change the release of glutamate neurotransmitter and affects the pathogenesis of epilepsy. However, the mechanisms of LGI1 functions have not been fully understood. In this review, we will introduce recent progresses in the study of LGI1 in epilepsy-related diseases, and discuss possible therapeutics for these diseases.