脂联素水平与2型糖尿病及心血管疾病矛盾性关系的研究进展

Advances of the Contradictory Relationship between Plasma Adiponectin Level and Type 2 Diabetes Mellitus and Cardiovascular Disease

脂联素作为脂肪细胞产生和分泌的一种细胞因子,在细胞和动物的基础实验中,脂联素已被证实具有胰岛素增敏、抗炎、抗氧化、抗动脉粥样硬化和抗凋亡等作用。然而在大规模人群的流行病学和基因组学的研究中,脂联素的这些有益作用却不能够完全再现。该文将对循环中脂联素水平与2型糖尿病、心血管疾病矛盾性关系进行归纳与总结,并对其矛盾性关系的原因给予阐述及分析,旨在为今后进一步研究脂联素在2型糖尿病及心血管疾病中的作用提供科学依据。

As a cytokine produced and secreted by the adipocyte, adiponectin has been confirmed with sensitization, anti-inflammatory, antioxidant, anti-atherosclerosis and anti-apoptosis in the cell and animal experiments. However, in the epidemiologic and genomic research in large population, these beneficial effects of adiponectin are not able to compeletely reproduction. This review aims to induce and summarize the contradictory relationship of adiponectin and type 2 diabetes mellitus, cardiovascular disease, and then analysis of the cause of this contradictory relationship, so that to provide a scientific basis for the further study of adiponectin in type 2 diabetes mellitues and cardiovascular disease.