自噬在脑卒中中的作用及其可能的机制

The Role of Autophagy in Stroke and Its Possible Mechanism

脑卒中是一种危害极大的神经系统疾病,而卒中导致的神经元死亡和损伤是该病的直接原因,所以拯救神经元对于治疗脑卒中来说至关重要。一直以来,脑神经元的死亡被认为有坏死、凋亡和自噬三种死亡途径,前两者都导致细胞死亡。近年来的研究发现,过度自噬确实导致细胞死亡,但是适度激活的自噬可能是神经元存活的关键。

Stroke is a serious neurological disease, the direct cause of which is the death and injury of neurons, so it is essential to save neurons for treating stroke. All the time, the death of brain neurons has been recognized as necrosis, apoptosis and autophagy, meanwhile necrosis and apoptosis cause the destruction of cells. However, recent studies have found that excessive autophagy does cause cell death, but a moderately activated autophagy could be crucial to the neuron survival.