急性髓系白血病发病机制的研究进展

Advances in the Pathogenesis Study of Acute Myeloid Leukemia

急性髓系白血病(acute myeloid leukemia,AML)是白血病中最常见的类型。传统治疗以联合化疗为主,而患者完全缓解率和长期无病生存率均较低。随着研究的深入,发现AML主要的发病机制包括融合基因、信号通路、白血病干细胞(leukemia stem cells,LSCs)以及骨髓微环境的改变等。该文旨在总结目前AML发生、发展机制的研究进展,并探讨其未来可能的治疗研究方向。

Acute myeloid leukemia（AML） is one of the most common malignant tumors. Traditional treatment is given priority to with combination chemotherapy, but complete remission or long-term disease-free survival rate is very low. With further investigation on the advanced research, it is stated that the major pathogenesis of AML include fusion gene, signal pathway, leukemia stem cells（LSCs） and bone marrow niche change. The main aim of this review is to summarize recent advanced development on AML mechanism and to further discuss the potential approaches to the treatment of AML.