糖尿病肾病动物模型研究进展

Research Progress of Laboratory Animal Models of Diabetic Neuropathy

糖尿病肾病是糖尿病的主要慢性并发症之一,是终末期肾病发生的主要原因。理想的糖尿病肾病动物模型对阐明其发病机制、更新临床防治策略具有重要意义。目前使用的糖尿病肾病动物模型主要包括诱发性、自发性和基因修饰糖尿病肾病模型等。本文就目前较常用的糖尿病肾病动物模型作一综述。

Diabetic nephropathy（DN）is one of the major chronic complications of diabetes mellitus,and is the main cause of end-stage renal disease.Ideal diabetic nephropathy animal models are important to clarify the pathogenesis of DN,and helpful for supplying effective prevention strategy.The current animal models of DN mainly include the induced,spontaneous,and genetically modified diabetic nephropathy models.This paper reviewed the progress of laboratory animal models of diabetic nephropathy.